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Details for Patent: 4,859,451

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Details for Patent: 4,859,451

Title: Paramagnetic contrast agents for MR imaging
Abstract:In the NMR imaging of a subject comprising administering to such subject a composition containing an image-modifying effective amount of an image enhancer, permitting the enhancer to move through the subject, and after a time interval taking an NMR image of the subject, the improvement which comprises employing as said enhancer a complex of a paramagnetic polyvalent metal and a partial amide and/or ester of diethylenetriaminepentaacetic acid. The complexes are new.
Inventor(s): Quay; Steven C. (Menlo Park, CA), Worah; Dilip M. (Menlo Park, CA)
Assignee: Salutar, Inc. (Sunnyvale, CA)
Filing Date:Apr 24, 1986
Application Number:06/855,223
Claims:1. A complex of a paramagnetic polyvalent metal and a derivative of diethylenetriaminepentaacetic acid of the formula ##STR4## in which from 1 to 4 M's are OH and the balance independently are OR, NH.sub.2, NHR or NRR, and

R is an alkyl radical of 1 to 18 carbon atoms.

2. A complex according to claim 1, wherein the metal is selected from the group consisting of a lanthanide, iron, manganese, copper, cobalt, chromium and nickel.

3. A complex according to claim 1, wherein the metal is selected from the group consisting of iron, manganese and gadolinium.

4. A complex according to claim 1, wherein two of the acid radicals of the diethylenetriaminepentaacetic acid are amide or ester substituted.

5. A complex according to claim 1 wherein an amide group is present and its nitrogen is substituted by at least one C.sub.1-18 -alkyl radical.

6. A complex according to claim 1, wherein the amide or ester radical includes at least one chain of at least 4 carbon atoms.

7. A complex according to claim 1, wherein the amide or ester radical includes at least one chain of at least 12 carbon atoms.

8. A complex according to claim 1, wherein the metal is iron.

9. A complex according to claim 6, wherein the metal is selected from the group consisting of iron, manganese and gadolinium.

10. In the NMR imaging of a subject comprising administering to such subject a composition containing an image-modifying effective amount of an image enhancer, permitting the enhancer to move through the subject, and after a time interval taking an NMR image of the subject, the improvement which comprises administering as said enhancer a complex according to claim 1.

11. A process according to claim 10, wherein the metal of the complex is selected from the group consisting of a lanthanide, iron, manganese, copper, cobalt, chromium and nickel.

12. A process according to claim 10, wherein the metal of the complex is selected from the group consisting of a iron, manganese, and gadolinium.

13. A process according to claim 10, wherein two of the acid radicals of the diethylenetriaminepentaacetic acid are amide or ester substituted.

14. A process according to claim 10, wherein an amide group is present and its nitrogen is substituted by at least one C.sub.1-18 -alkyl radical.

15. A process according to claim 10, wherein the amide or ester radical includes at least one chain of at least 4 carbon atoms.

16. A process according to claim 10, wherein the amide or ester radical includes at least one chain of at least 12 carbon atoms.

17. A process according to claim 13, wherein the metal is iron.
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