.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 4,857,334

« Back to Dashboard

Details for Patent: 4,857,334

Title: Synthetic resin matrix system incorporating healing enhancer
Abstract:An apparatus and method is described for applying epidermal growth factor (EGF) for achieving healing enhancement at a wound site. The human source of epidermal growth factor, designated as hEGF, is applied from the synthetic resin matrix system of this invention, and which comprises a polymer, such as poly(2-hydroxyl ethyl methyl methacrylate), referred to as PHEMA, an organic solvent, such as polyethylene glycol (PEG), and a hydrogen binding plasticizer, such as dimethylsulfoxide (DMSO). The plasticizer regulates the set-up time of the synthetic resin, so that the more plasticizer present, the shorter the set-up time. The dressing, once formed, and having the healing enhancer contained therein, may be sealed within various backing sheets, in order to preserve its aseptic condition. When ready for use, one of the backing sheets may be peeled away to expose the resin pad with the emobodied healing enhancer, ready for application to the wound site.
Inventor(s): Korol; Bernard (Highland Beach, FL), Nathan; Paul (Cincinnati, OH)
Assignee: Enquay Pharmaceutical Associates (Boca Raton, FL)
Filing Date:May 27, 1988
Application Number:07/199,375
Claims:1. A synthetic resin matrix system for drug storage and extended duration drug release comprising a particulate, hydrophilic, water swellable polymer, and inert, non-toxic water miscible organic solvent, and a hydrogen bonding plasticizer; said polymer selected from the group consisting of a synthetic resin matrix system for drug storage and extended duration drug release comprising a particulate, hydrophilic, water swellable polymer, an inert, non-toxic water miscible organic solvent, and a hydrogen bonding plasticizer, said polymer selected from the group consisting of hydroxy(C.sub.2 -.sub.4 alkyl) methacrylate, hydroxy(C.sub.2 -.sub.4 alkyl) acrylate, hydroxy(C.sub.2 -.sub.4 alkoxyC.sub.2 -.sub.4 alkyl) methacrylate, hydroxy(C.sub.2 -.sub.4 alkoxyC.sub.2 -.sub.$ alkyl) acrylate, alkoxy(C.sub.2 -.sub.4 alkoxyC.sub.2 -.sub.4 alkyl) methacrylate, alkoxy(C.sub.2 -.sub.4 alkoxyC.sub.2 -.sub.4 alkyl)acrylate, N-(C.sub.1 -.sub.4 alkyl) acrylamide, N-(C.sub.1 -.sub.4 alkyl) methacrylamide, N,N-di(C.sub.1 -.sub.4 alkyl) acrylamide, N,N-di(C.sub.1 -.sub.4 alkyl) methacrylamide, vicinal-epoxy(C.sub.1 -.sub.4 alkyl) methacrylate, or vicinal-epoxy(C.sub.1 -.sub.4 alkyl) acrylate, said solvent selected from the group consisting of polyethylene glycol or polypropylene glycol having a molecular weight averaging between about 200-2000 gram molecular weight units, and wherein said plasticizer being selected from the group consisting of dimethylsulfoxide, dimethylphthalate, 2,3-butylene carbonate, dimethylformamide, dimethyltetramethylene sulfone, diethylsulfone, methylene glycolate, methylpropyl sulfone, or butyrolactone, with said polymer ranging between about 15%-50% by weight of said matrix system, with said solvent ranging between about 30%-65% by weight of said matrix system, with said plasticizer ranging up to about 20% by weight of said matrix system, and further including a medicament agent for local or systemic therapeutic effects, said medicament agent being a growth factor or healing enhancer.

2. The invention of claim 1 and wherein said healing enhancer is an epidermal growth factor (EGF).

3. The invention of claim 2 and wherein said EGF is equivalent to human derived material (hEGF) comprising a polypeptide containing 53-amino acids and having a molecular weight of approximately 5,000 gram molecular weight units.

4. The invention of claim 3 and including a pair of backing sheets, and said matrix system with healing enhancer being arranged intermediate said sheets.

5. The invention of claim 4 and wherein said sheets being transparent.

6. The invention of claim 4 and wherein one of said backing sheets being elastic.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc