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Details for Patent: 4,847,244

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Details for Patent: 4,847,244

Title: Treatment of human viral infections
Abstract:Treatments of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of the 5'-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose.
Inventor(s): Rideout; Janet L. (Raleigh, NC), Barry; David W. (Chapel Hill, NC), Lehrman; Sandra N. (Durham, NC), St. Clair; Martha H. (Durham, NC), Furman; Phillip A. (Durham, NC)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Filing Date:Oct 20, 1987
Application Number:07/110,947
Claims:1. A method of treating a human having HTLV III virus infection comprising administering an effective HTLV III virus infection treatment amount of the 5'-monophosphate of 3'-azido-3'-dexoythymidine to said human.

2. The method of claim 1 in which the 5'-monophosphate of 3'-azido-3'-deoxythymidine is orally administered.

3. The method of claim 1 in which the 5'-monophosphate of 3'-azido-3'-deoxythymidine is parenterally administered.

4. A method of treating a human having a HTLV III virus infection comprising administering an effective HTLV III virus infection treatment amount of the 5'-diphosphate of 3'-azido-3'-deoxythymidine to said human.

5. The method of claim 4 in which the 5'-diphosphate of 3'-azido-3'-deoxythymidine is orally administered.

6. The method of claim 4 in which the 5'-diphosphate of 3'-azido-3'-deoxythymidine is parenterally administered.

7. The method of claim 4 in which said salt is orally administered.

8. The method of claim 4 in which said salt is parenterally administered.

9. A method of treating a human having a HTLV III virus infection comprising administering an effective HTLV III virus infection treatment amount of the 5'-triphosphate of 3'-azido-3'-deoxythymidine to said human.

10. The method of claim 9 in which the 5'-triphosphate of 3'-azido-3'-deoxythymidine is orally administered.

11. The method of claim 9 in which the 5'-triphosphate of 3'-azido-3'-deoxythymidine is parenterally administered.

12. The method of claim 1, 4 or 9 in which the human has AIDS or AIDS related complex.

13. The method of claim 1, 4, or 9 in which the human has antibodies to the HTLV III virus.

14. A method of treating a human having HTLV III virus infection comprising administering an effective HTLV III virus infection treatment amount of a pharmaceutically accepable salt of the 5'-monophosphate of 3'-azido-3'-deoxythymidine to said human.

15. The method of claim 14 in which said salt is orally administered.

16. The method of claim 14 in which said salt is parenterally administered.

17. A method of treating a human having a HTLV III virus infection comprising administering an effective HTLV III virus infection treatment amount of a pharmaceutically acceptable salt of 5'-diphosphate of 3'-azido-3'-deoxythymidine to said human.

18. A method of treating a human having a HTLV III virus infection comprising administering an effective HTLV III virus infection treatment amount of a pharmaceutically acceptable salt of the 5'-triphosphate of 3'-azido-3'deoxythymidine to said human.

19. The method of claim 18 in which said salt is orally administered.

20. The method of claim 18 in which said salt is parenterally administered.

21. The method of claims 14, 17 or 18 in which the human has AIDS or AIDS related complex.

22. The method of claims 14, 17 or 18 in which the human has antibodies to the HTLV III virus.
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