|Title:||Pulsed drug delivery of doxylamine|
|Abstract:||A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.|
|Inventor(s):||Ayer; Atul D. (Mountain View, CA), Theeuwes; Felix (Los Altos, CA), Wong; Patrick S. (Hayward, CA)|
|Assignee:||Alza Corporation (Palo Alto, CA)|
|Filing Date:||May 09, 1986|
|Claims:||1. A single dosage form comprising two doses of a beneficial drug formulation useful as a sleep-aid for administering to a recipient, said dosage form comprising: |
(a) a dosage amount of a first dose of a doxylamine formulation coated on the exterior surface of the dosage form;
(b) a first wall comprising in at least a part a semipermeable composition permeable to the passage of fluid, said wall surrounding;
(c) a second wall comprising means for delaying release of a doxylamine formulation from the interior of the dosage form, said second wall surrounding;
(d) a first layer comprising a second dose of a doxylamine formulation;
(e) a second layer comprising a hydrophilic hydrogel formulation that swells in the presence of fluid; and,
(f) at least one exit means in the wall for releasing doxylamine formulation from the interior of the dosage form.
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