|Title:|| Pharmaceutical composition containing a liquid lubricant|
|Abstract:||Pharmaceutical compositions produced with liquid, hydrophilic lubricants possessing markedly improved dissolution rates.|
|Inventor(s):|| Hersh; Marvin (Strafford, PA), Lentine; Charles W. (Brookhaven, PA) |
|Assignee:|| American Home Products Corporation (New York, NY) |
|Filing Date:||Jul 21, 1986|
|Claims:||1. A solid pharmaceutical composition free of solid hydrophobic lubricant comprising a dry, powdery, dust-producing formulation of a therapeutic agent, in intimate admixture with a non-solubilizing amount of a pharmaceutically acceptable, liquid, hydrophilic, dust-reducing, lubricant, said lubricant being a polyethylene glycol of molecular weight from about 200 to about 900, present in said admixture in from about 0.2 to about 5 weight percent of composition. |
2. A solid pharmaceutical composition of claim 1 in which said polyethylene glycol has a molecular weight of about 380 to about 420.
3. A solid pharmaceutical composition of claim 1 in which said admixture contains a pharmaceutically acceptable surface active agent.