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Details for Patent: 4,820,292

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Details for Patent: 4,820,292

Title: Anti-microbial sensitivity test and testing stratum
Abstract:An anti-microbial sensitivity test and testing stratum is disclosed for evaluating the sensitivity of different anti-microbial agents relative to identifiable microbial contaminants. The test stratum comprises a polymer such as poly(2-hydroxyethylmethacrylate) referred to as PHEMA, an organic solvent, such as polyethylene glycol (PEG), a hydrogen binding plasticizer, such as dimethylsulfoxide (DMSO), an an anti-microbial agent such as silver sulfadiazine, mafenide, nystatin, nitrofurazone, silver nitrate, bacitracin, gentamicin, amphotericin B, cesium nitrate, or other anti-microbial agents. The test includes positioning testing stratum of the type described, each having a different anti-microbial agent therein, on a sterile plate or on an agar substrate and spaced in fixed relationship to one another. The testing stratum are self adhering and remain fixed on a sterile plate, or on an applicator, even when the sterile plate, is inverted. The testing stratum further provide a sustained release of the anti-microbial agent incorporated therein. The testing stratum are then subjected to samples from the wound site, often containing microbial contaminants, and after a predetermined period of incubation, evaluation indicative of microbial contamination can then be made and examination of the zones of inhibition over and around each of the anti-microbial testing stratum will determine effectiveness of each anti-microbial agent contained in the test system.
Inventor(s): Korol; Bernard (Highland Beach, FL), Nathan; Paul (Cincinnati, OH)
Assignee: Enguay Pharmaceutical Associates (Boca Raton, FL)
Filing Date:May 27, 1988
Application Number:07/199,379
Claims:1. An anti-microbial sensitivity testing stratum for evaluating the sensitivity of anti-microbial agents relative to identifiable microbial contaminants, said stratum comprising a particulate, hydrophilic, water swellable polymer of an acrylate or acrylamide ranging approximately from 20%-55% by weight of said stratum; a hydrogen bonding plasticizer of dimethysulfoxide ranging approximately up to 20% by weight of said stratum; an inert, non-toxic water miscible organic solvent of polyethylene glycol ranging approximately 20%-65% by weight of said stratum; and an anti-microbial agent, constituting the remainder by weight of said stratum.

2. The anti-microbial sensitivity testing stratum as defined in claim 1 wherein said polymer is poly (2-hydroxyethylmethacrylate), said plasticizer is dimethyl sulfoxide, and said solvent is polyethylene glycol having a molecular weight of about 200-2000.

3. The anti-microbial sensitivity testing stratum as defined in claim 2 wherein said anti-microbial agent has a range approximately up to 10% by weight of said stratum.

4. The anti-microbial sensitivity testing stratum as defined in claim 3 wherein said anti-microbial agent is silver sulfadiazine having about 1% by weight of said stratum.

5. The anti-microbial sensitivity testing stratum as defined in claim 3 wherein said anti-microbial agent is mafenide having about 5% by weight of said stratum.

6. The anti-microbial/sensitivity testing stratum as defined in claim 3 wherein said anti-microbial agent is nystatin having about 1.7% by weight of said stratum.

7. The anti-microbial sensitivity testing stratum as defined in claim 3 wherein said anti-microbial agent is nitrofurazone having about 0.2% by weight of said stratum.

8. The anti-microbial sensitivity testing stratum as defined in claim 3 wherein said anti-microbial agent is silver nitrate having about 0.5% by weight of said stratum.

9. The anti-microbial sensitivity testing stratum as defined in claim 3 wherein said anti-microbial agent is bacitracin having about 0.83% by weight of said stratum.

10. The anti-microbial sensitivity testing stratum as defined in claim 2 wherein said anti-microbial agent is gentamicin.

11. The anti-microbial sensitivity testing stratum as defined in claim 2 wherein said anti-microbial agent is amphotericin B.

12. The anti-microbial sensitivity testing stratum as defined in claim 2 wherein said anti-microbial agent is cesium nitrate.

13. The process of evaluating the sensitivity of different anti-microbial agents relative to a particular microbial contaminant(s) which includes the steps of providing a plurality of anti-microbial sensitivity testing stratum as defined in claim 2, each having a sustained release anti-microbial agent of different composition therein, positioning each of the testing stratum on a sterile plate in spaced relationship to one another, subjecting each of the testing stratum and intermediate portions of the sterile plate to the microbial contaminant being tested, and evaluating any zones of inhibition over and around each of said anti-microbial agent in inhibiting the growth of the particular microbial contaminant(s).
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