Process for the treatment of hyperpigmentary dermatoses including malignant melanomas
There is disclosed a composition for the treatment of acne, hyperpigmentary dermatoses or skin hyperpigmentation which contains dicarboxylic acids containing 7 to 13 carbon atoms or certain derivatives thereof that contain reducing functional group or a salt thereof. There are also disclosed methods for preparing mercapto derivatives of these discarboxylic acids.
Nazzaro-Porro; Marcella (Rome, IT)
Schering AG (Berlin, DE)
Jan 29, 1982
1. A method for the treatment of individuals exhibiting a malignant melanoma or a circumscribed precancerous melanosis of Dubreuihl condition which comprises administering to said individual a therapeutically effective amount of at least one dicarboxylic acid selected from the group consisting of azelaic acid and dodecandioic acid, in a phramaceutically acceptable carrier until said condition is reduced or its further development is arrested.
2. A method as defined in claim 1, wherein said acid is azelaic acid.
3. A method as defined in claim 2 wherein said individual exhibits a malignant melanoma condition.
4. A method as defined in claim 2 wherein said individual exhibits a circumscribed pre-cancerous melanosis of Dubreuilh condition.
5. A method as defined in claim 1 wherein said acid is dodecandioic acid.
6. A method as defined in claim 5 wherein said individual exhibits a malignant melanoma condition.
7. A method as defined in claim 5 wherein said individual exhibits a circumscribed pre-cancerous melanosis of Dubreuilh condition.
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