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Details for Patent: 4,818,750

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Details for Patent: 4,818,750

Title: Treatment of human viral infections
Abstract:Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically basic salt thereof. Also disclosed is the use of the 5'-mono-, di- and triphosphate of 3'-azido-3'-dexoythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose.
Inventor(s): Rideout; Janet L. (Raleigh, NC), Barry; David W. (Chapel Hill, NC), Lehrman; Sandra N. (Durham, NC), St. Clair; Martha H. (Durham, NC), Furman; Phillip A. (Durham, NC)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Filing Date:Oct 20, 1987
Application Number:07/110,968
Claims:1. A method of increasing the number of T-lymphocytes in a human infected with the HTLV III virus comprising administering to said human an effective amount of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable alkali metal, alkaline earth or ammonium salt thereof.

2. The method of claim 1 which comprises administering 3'-azido-3'-deoxythymidine to said human.

3. The method of claim 1 which comprises administering the sodium salt of 3'-azido-3'-deoxythymidine to said human.

4. A method of increasing the number of T-Lymphocytes in a human infected with the HTLV III virus comprising administering to said human an effective amount of 5'-mono-, di- or triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable alkali metal, alkaline earth or ammonium salt thereof.
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