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Generated: March 22, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,808,585

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Title: Solutions of lactic acid salts of piperazinylquinolone- and piperazinyl-azaquinolone-carboxylic acids
Abstract:The invention relates to solutions of piperazinylquinolone- and piperazinyl-azaquinolone-carboxylic acids, and in particular both ready-to-use injection and/or infusion solutions and dosage forms which can be converted into such injection and/or infusion solutions before use. The solutions according to the invention are characterized in that, besides the lactic acid salts of the active substance and, if appropriate, customary auxiliaries, they additonally contain at least one acid which does not lead to precipitates, in particular lactic acid.
Inventor(s): Grohe; Klaus (Odenthal, DE), Lammens; Robert (Leverkusen, DE)
Assignee: Bayer Aktiengesellschaft (Leverkusen, DE)
Filing Date:May 12, 1986
Application Number:06/862,343
Claims:1. An aqueous storage stable solution which can be converted into an injection or diffusion solution consisting essentially of (a) a lactic acid salt of a piperazinylquinolonecarboxylic acid of the formula ##STR2## in which R.sub.1 denotes hydrogen, methyl, ethyl or .beta.-hydroxyethyl,

R.sub.3 denotes hydrogen, methyl or ethyl,

and (b) and excess acid selected from the group consisting of methanesulphonic acid, propionic acid, succinic acid, hydrochloric acid and lactic acid in an amount which does not lead to precipitates and constituting about 0.01 to 90% based on the solution.

2. A solution according to claim 1, wherein the excess acid is present in about 0.01 to 25%.

3. A solution according to claim 1, wherein the excess acid is present in the solution in a concentration of from 0.025 to 1.4%.

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Serving hundreds of leading biopharmaceutical companies globally:

Cantor Fitzgerald
Boehringer Ingelheim
Johnson and Johnson

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