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Details for Patent: 4,780,453

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Details for Patent: 4,780,453

Title: Treatment of feline viral infections
Abstract:Treatment of cats carrying or infected with the Feline Leukemia virus or having antibodies to the Feline leukemia virus is disclosed using the compound 3'-azido''-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of the 5'-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose.
Inventor(s): Rideout; Janet L. (Raleigh, NC), Barry; David W. (Chapel Hill, NC), Lehrman; Sandra N. (Durham, NC), St. Clair; Martha H. (Durham, NC), Furman; Phillip A. (Durham, NC)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Filing Date:Dec 23, 1986
Application Number:06/945,234
Claims:1. A method of treating a cat infected with Feline leukemia virus comprising administering to said cat an effective Feline leukemia virus antiviral treatment amount of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable alkali metal, alkaline earth or ammonium salt thereof.

2. A method of claim 1 in which 3'-azido-3'-deoxythymidine is administered to the cat.

3. A method of treating a cat infected with Feline leukemia virus comprising administering to said cat an effective Feline leukemia virus antiviral treatment amount of the 5'-mono-, di- or triphosphate of 3'-azido-3'-deoxythymidine or an alkali metal, alkaline earth or ammonium salt thereof.

4. A method of inhibiting the replication of the Feline leukemia virus in a cat infected with or having antibodies to FeLV which comprises administering an effective Feline leukemia virus replication inhibition amount of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable salt or the 5'-mono-, di- or triphosphate thereof or a pharmaceutically acceptable salt of the said phosphate thereof to a cat in need thereof.
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