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Details for Patent: 4,777,048

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Details for Patent: 4,777,048

Title: Pharmaceutical composition containing a liquid lubricant
Abstract:Pharmaceutical compositions produced with liquid, hydrophilic lubricants possessing markedly improved dissolution rates.
Inventor(s): Hersh; Marvin (Strafford, PA), Lentine; Charles W. (Brookhaven, PA)
Assignee: American Home Products Corporation (New York, NY)
Filing Date:Jul 18, 1986
Application Number:06/886,699
Claims:1. In a method for filling a hard gelatin, telescoping two-piece cap and body capsule with a dry, dust-producing, solid pharmaceutical composition containing a therapeutic agent, the improvement of reducing atmosphere dust which consists essentially of the step of incorporating into said pharmaceutical composition not more than an effective lubricating amount of a pharmaceutically acceptable, hydrophilic, dust-reducing, liquid polyalkylene glycol to provide proper flow characteristics to said composition.

2. In the method of claim 1, the improvement in which said polyalkylene glycol is polyethylene glycol of molecular weight from about 200 to about 900.

3. In a method for filling a hard gelatin, telescoping two-piece cap and body capsule with a dry, dust-producing, solid pharmaceutical composition containing a therapeutic agent, the improvment which comprises reducing atmospheric dusts produced during the capsule filling operation by incorporating into said pharmaceutical composition not more than an effective lubricating, dust-reducing amount of a pharmaceutically acceptable, hydrophilic, liquid polyethylene glycol of molecular weight from about 200 to about 900, said polyethylene glycol being incorporated into said composition in an amount from about 0.5 to about 25 weight percent of said composition.
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