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Generated: April 26, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,761,501

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Title: Substituted phenylacetamides
Abstract:This application discloses certain substituted phenylacetamides of the formula: ##STR1## in which the dotted line represents optional unsaturation, R.sub.1 is alkyl; R.sub.2 is alkyl; R.sub.4 is hydrogen or alkyl; R.sub.5 and R.sub.6, one of which may be hydrogen, are independently, hydroxyl, alkyl, alkoxy, aralkoxy, alkanoyloxy, alkylmercapto, N-protected amino, halo or trifluoromethyl; R.sub.7 is hydrogen or alkyl; and n is one of the integers 0, 1, 2, 3 or 4; which are useful in the production of antidepressant agents.
Inventor(s): Husbands; G. E. Morris (Berwyn, PA), Yardley; John P. (Gulph Mills, PA), Muth; Eric A. (West Chester, PA)
Assignee: American Home Products Corporation (New York, NY)
Filing Date:May 22, 1985
Application Number:06/736,744
Claims:1. A compound of the formula: ##STR16## in which the dotted line represents optional unsaturation, R.sub.1 is alkyl of 1 to 6 carbon atoms;

R.sub.2 is alkyl of 1 to 6 carbon atoms;

R.sub.4 is hydrogen or alkyl of 1 to 6 carbon atoms;

R.sub.5 and R.sub.6, one of which may be hydrogen, are independently, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, aralkoxy of 7 to 9 carbon atoms, alkanoyloxy of 2 to 7 carbon atoms, alkylmercapto of 1 to 6 carbon atoms, N-protected amino, halo or trifluoromethyl;

R.sub.7 is hydrogen or alkyl of 1 to 6 carbon atoms; and

n is one of the integers 0, 1, 2, 3 or 4.

2. The compound of claim 1 which is 1-[(4-bromophenyl)[(dimethylamino)carbonyl]methyl]cyclohexanol.

3. The compound of claim 1 which is 1-[(3-bromophenyl)[(dimethylamino)carbonyl]methyl]cyclohexanol.

4. The compound of claim 1 which is 1-[(3-chlorophenyl)[(dimethylamino)carbonyl]methyl]cyclohexanol.

5. The compound of claim 1 which is 1-[(2-chlorophenyl)[(dimethylamino)carbonyl]methyl]cyclohexanol.

6. The compound of claim 1 which is 1-[(3,4-dichlorophenyl)[(dimethylamino)carbonyl]methyl]cyclohexanol.

7. The compound of claim 1 which is 1-[(3-methoxyphenyl)[(dimethylamino)carbonyl]methyl]cyclohexanol.

8. The compound of claim 1 which is 1-[(3,4-dimethoxyphenyl)[(dimethylamino)carbonyl]methyl]cyclohexanole.

9. The compound of claim 1 which is 1-[(4-trifluoromethylphenyl)[(dimethylamino)carbonyl]methyl]cyclohexanol.

10. The compound of claim 1 which is 1-[(3-trifluoromethylphenyl)[(dimethylamino)carbonyl]methyl]cyclohexanol.

11. The compound of claim 1 which is 1-[(4-methylphenyl)[(dimethylamino)carbonyl]methyl]cyclohexanol.

12. The compound of claim 1 which is 1-[(4-benzyloxyphenyl)[(dimethylamino)carbonyl]methyl]cyclohexanol.

13. The compound of claim 1 which is 1-[(3-benzyloxyphenyl)[(dimethylamino)carbonyl]methyl]cyclohexanol.

14. The compound of claim 1 which is 1-[(4-bromophenyl)[(dimethylamino)carbonyl]methyl]cyclobutanol.

15. The compound of claim 1 which is 1-[(4-methoxyphenyl)[(dimethylamino)carbonyl]methyl]cyclopentanol.

16. The compound of claim 1 which is 1-[(4-methoxyphenyl)[(dimethylamino)carbonyl]methyl]cycloheptanol.

17. The compound of claim 1 which is 1-[(4-methoxyphenyl)[)dimethylamino)carbonyl]methyl]cyclooctanol.

18. The compound of claim 1 which is 1-[(4-methoxyphenyl)[(dimethylamino)carbonyl]methyl]cyclohex-2-en-1-ol.

19. The compound of claim 1 which is 1-[(4-aminophenyl)[(dimethylamino)carbonyl]methyl]cyclohexanol.

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