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|Title:||Sulfamoyl-substituted phenethylamine derivatives, their preparation, and pharmaceutical compositions, containing them|
|Abstract:||A novel process is provided for the preparation of optical isomers of certain sulfamoyl-substituted phenethylamine derivatives which exhibit .alpha.-adrenergic blocking agents which can be used for various treatments such as for the treatment of congestive heart failure.|
|Inventor(s):||Niigata; Kunihiro (Saitama, JP), Fujikura; Takashi (Saitama, JP)|
|Assignee:||Yamanouchi Pharmaceutical Co., Ltd. (Tokyo, JP)|
|Filing Date:||Feb 10, 1986|
|Claims:||1. A process of producing (R)(-)-5-[2-[[2-(o-ethoxyphenoxy)ethyl]amino-2-methylethyl]-2-methoxybenze nesulfonamide, which comprises reacting (R)(-)-5-[(2-amino-2-methyl)ethyl]-2-methoxybenzenesulfonamide with 2-(o-ethoxyphenoxy)ethyl bromide. |
2. A process of producing (S)(+)-5-[2-[[2-(o-ethoxyphenoxy)ethyl]amino]-2-methylethyl]-2-methoxybenz enesulfonamide, which comprises reacting (S)(+)-5-[(2-amino-2-methyl)ethyl]-2-methoxybenzenesulfonamide with 2-(o-ethoxyphenoxy)ethyl bromide.
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