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Details for Patent: 4,754,050

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Details for Patent: 4,754,050

Title: 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
Abstract:There are disclosed compounds having the formula ##STR1## wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR.sub.2 where R.sub.2 is loweralkyl, or NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R.sub.1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl; Y is C.dbd.O or CR.sub.5 OH where R.sub.5 is hydrogen or loweralkyl; Z is CH.sub.2 or C.dbd.CR.sub.6 R.sub.7 where R.sub.6 and R.sub.7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR.sub.5 .dbd.CH where CR.sub.5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.
Inventor(s): Shutske; Gregory M. (Somerset, NJ), Pierrat; Frank A. (Coventry, RI)
Assignee: Hoechst-Roussel Pharmaceuticals, Inc. (Somerville, NJ)
Filing Date:Nov 25, 1987
Application Number:07/125,526
Claims:1. A compound having the formula ##STR20## wherein n is 1, 2 or 3 and X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR.sub.2 where R.sub.2 is loweralkyl, or NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl.

2. The compound as defined in claim 1, where n is 2.

3. The compound as defined in claim 2, which is 2-(3-oxocyclohexen-1-yl)aminobenzonitrile.

4. The compound as defined in claim 2, which is 5-chloro-2-(3-oxocyclohexen-1-yl)aminobenzonitrile.

5. The compound as defined in claim 2, which is 4-chloro-2-(3-oxocyclohexen-1-yl)aminobenzonitrile.
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