Process and composition for reducing intraocular pressure and reducing aqueous humor formation by applying topically to the cornea an effective amount of an aqueous solution of a caronic anhydrase inhibitor comprising a sulfonamide having the following properties: a. sufficiently soluble in water to form at least a 3 mM solution at pH 8.2 or a pKa of not greater than 7.3; b. ether partition coefficient of at least 1.0; c. chloroform partition coefficient of at least 0.01; d. dissociation constant against carbonic anhydrase of not more than 3.times.10.sup.-8 molar; e. first order rate constant for penetration of the sulfonamide through a living rabbit cornea of at least 0.005 hr.sup.-1 ; f. not injurious to the cornea; and g. stable in aqueous solution and in contact with the cornea.
Maren; Thomas H. (N/A)
Jun 19, 1986
1. The compound 2-trifluoroacetylimino-3-methyl-.DELTA..sup.2 -1,3,4-thiadiazoline-5-sulfonamide.
2. The compound 2-trichloroacetylimino-3-methyl-.DELTA..sup.2 -1,3,4-thiadiazoline-5-sulfonamide.
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