Proactively manage your pharmacy inventory
Deep knowledge on
small-molecule drugs and
the 110,000 global patents
Drug patents …
… from Kazakhstan to Kalamazoo
Anticipate generic drug launch
Manage your formulary budget
Find generic entry opportunities
Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Anti-inflammatory products derived from methylene-diphosphonic acid, and process for their preparation|
|Abstract:||The present invention relates to products of the formula ##STR1## where R.sub.1 is H or alkyl, n is an integer from 0 to 10, and R.sub.2 is chosen from amongst H, unsubstituted or substituted alkyl radicals, a ##STR2## a substituted or unsubstituted phenyl radical, a ##STR3## where X is oxygen or sulfur, or a heterocyclic radical with 5 or 6 members, which may or may not be fused to a benzene ring and R.sub.3 is H or OH. The present invention also relates to a process for the preparation of the products of the formula (I), and to the drugs, having in particular an anti-inflammatory effect, containing a product of the formula (I).|
|Inventor(s):||Breliere; Jean C. (Montpellier, FR), Emonds-Alt; Xavier (Montpellier, FR), Garcia; Georges (Saint-Gely-du-Fesc, FR)|
|Assignee:||Sanofi (Paris, FR)|
|Filing Date:||Apr 24, 1986|
|Claims:||1. A method for treating inflamation which comprises administering to an animal in need of such treatment an anti-inflammatory effective amount of a methylene-diphosphonic acid compound having the formula ##STR56## in which: R.sub.1 is hydrogen or a straight or branched lower alkyl group having from 1 to 4 carbon atoms, |
an alkyl group having from 1 to 16 carbon atoms which is unsubstituted or substituted by a phenyl group, a hydroxyl group, a thiol group, one or more halogen atoms, ##STR57## where Z.sub.1 and Z.sub.2, considered independently of one another, are hydrogen or a lower alkyl group,
a phenyl group which is unsubstituted or substituted one or more times by halogen, a nitro group, a lower alkyl group, a lower alkoxy group, trifluoromethyl, an NH.sub.2 group, or a COOH group, or ##STR58## where X is oxygen or sulfur and Z.sub.1 and Z.sub.2 are as defined above, R.sub.3 is hydrogen or a hydroxyl group, and
n is an integer between 0 and 10, except that n cannot be 0 if R.sub.3 is OH, or a salt of such compound with an organic or inorganic bases when R.sub.1 =H.
2. The method of claim 1 wherein the anti-inflammatory effective amount contains from 10 to 500 mg and is administered orally, endorectally, or parenterally.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.