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Generated: October 23, 2017

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Title: (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
Abstract:(S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide, its preparation and pharmaceutical compositions containing the same. It can be prepared either by reacting (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetic acid successively with an alkyl haloformate and with ammonia, or, by cyclizing an (S)-2-aminobutanamide of the formula X--CH.sub.2 CH.sub.2 --Y--NHCH(C.sub.2 H.sub.5)CONH.sub.2 wherein Y is a --CH.sub.2 -- radical when X represents a ZOOC-- radical and Y is a --CO-- radical when X represents a HalCH.sub.2 -- radical, Z being a C.sub.1 -C.sub.4 alkyl radical and Hal a halogen atom. This laevorotatory enantiomer has been found to have significantly higher protective activity against hypoxia and ischemia than the corresponding racemate.
Inventor(s): Gobert; Jean (Brussels, BE), Geerts; Jean-Pierre (Leglise, BE), Bodson; Guy (Bellefontaine, BE)
Assignee: U C B Societe Anonyme (Brussels, BE)
Filing Date:May 14, 1985
Application Number:06/733,790
Claims:1. A method for achieving an anti-hypoxia and anti-ischemia effect in a patient in need thereof, which comprises administering to said patient an effective amount of (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide.
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Serving leading biopharmaceutical companies globally:

Baxter
Healthtrust
Cerilliant
Chinese Patent Office
Farmers Insurance
Daiichi Sankyo
Cantor Fitzgerald
Citi
Mallinckrodt
Merck

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