Generated: April 26, 2017
|Title:||Treatment of memory impairment using (R)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide|
|Abstract:||(R)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide, its preparation and pharmaceutical compositions containing the same. It can be prepared either by reacting (R)-alpha-ethyl-2-oxo-1-pyrrolidineacetic acid successively with an alkyl haloformate and with ammonia, or, by cyclizing an (R)-2-amino-butanamide of the formula X--CH.sub.2 CH.sub.2 --Y--NHCH(C.sub.2 H.sub.5)CONH.sub.2 wherein Y is a --CH.sub.2 -- radical when X represents a ZOOC-- radical and Y is a --CO-- radical when X represents a HalCH.sub.2 -- radical, Z being a C.sub.1 -C.sub.4 alkyl radical and Hal a halogen atom. This dextrorotatory enantiomer has been found to have significantly higher mnemic activity and lower toxicity than the corresponding racemate.|
|Inventor(s):||Gobert; Jean (Brussels, BE), Giurgea; Corneliu (Brussels, BE), Geerts; Jean-Pierre (Leglise, BE), Bodson; Guy (Bellefontaine, BE)|
|Assignee:||UCB Societe Anonyme (Brussels, BE)|
|Filing Date:||May 14, 1985|
|Claims:||1. A method for treating memory impairment in a patient in need thereof which comprises administering to said patient an effective amount of (R)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide.|
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