Generated: May 25, 2017
|Title:||Difluoro antivirals and intermediate therefor|
|Abstract:||A 2,2-difluoro-2-desoxycarbohydrate is used to prepare antiviral nucleosides.|
|Inventor(s):||Hertel; Larry W. (Indianapolis, IN)|
|Assignee:||Eli Lilly and Company (Indianapolis, IN)|
|Filing Date:||Dec 04, 1984|
|Claims:||1. A nucleoside of the formula ##STR11## wherein R is a base of the formula ##STR12## wherein R.sup.2 is amino; |
R.sup.3 is hydrogen, bromo, chloro or iodo.
2. A nucleoside of claim 1 wherein the carbohydrate moiety is in the ribose form.
3. A method of treating Herpes viral infections in mammals comprising administering to a mammal in need of such treatment an anti-Herpes viral effective amount of a compound of claim 1.
4. A pharmaceutical composition useful for treating Herpes viral infections comprising an anti-Herpes viral effective amount of a compound of claim 1 and a pharmaceutically-acceptable carrier, diluent or excipient therefor.
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