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Details for Patent: 4,692,434

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Details for Patent: 4,692,434

Title: Difluoro antivirals and intermediate therefor
Abstract:A 2,2-difluoro-2-desoxycarbohydrate is used to prepare antiviral nucleosides.
Inventor(s): Hertel; Larry W. (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Filing Date:Dec 04, 1984
Application Number:06/677,146
Claims:1. A nucleoside of the formula ##STR11## wherein R is a base of the formula ##STR12## wherein R.sup.2 is amino;

R.sup.3 is hydrogen, bromo, chloro or iodo.

2. A nucleoside of claim 1 wherein the carbohydrate moiety is in the ribose form.

3. A method of treating Herpes viral infections in mammals comprising administering to a mammal in need of such treatment an anti-Herpes viral effective amount of a compound of claim 1.

4. A pharmaceutical composition useful for treating Herpes viral infections comprising an anti-Herpes viral effective amount of a compound of claim 1 and a pharmaceutically-acceptable carrier, diluent or excipient therefor.
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