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Details for Patent: 4,687,660

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Details for Patent: 4,687,660

Title: Pharmaceutical delivery system
Abstract:A composition for use in an aqueous environment which comprise a formulation containing a water-soluble pharmaceutically beneficial agent, a water-insoluble, water-permeable film coating surrounding the formulation, and particulate, water-soluble, pore-forming material dispersed within the film coating.
Inventor(s): Baker; Richard W. (Mountain View, CA), Brooke; James W. (Sisters, OR)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Filing Date:Aug 15, 1984
Application Number:06/640,951
Claims:1. A tablet comprising a core containing the admixture of a water-soluble medicine and a water-soluble osmotic enhancing agent in an amount by weight about equal to or greater than the weight of the medicine, said core having a water-insoluble, water-permeable coating surrounding said core, said coating containing particulate, water-soluble, pore-forming material dispersed therein.

2. The tablet of claim 1 in which the osmotic enhancing agent is a pharmaceutically acceptable water-soluble sugar or salt.

3. The tablet of claim 2 in which the pore forming material dispersed in the coating is a pharmaceutically acceptable water-soluble sugar or salt.

4. The tablet of claim 1 in which the osmotic enhancing agent and the pore-forming material are both lactose.

5. A composition comprising a core containing the admixture of a water-soluble medicine and a water-soluble osmotic enhancing agent in an amount by weight about equal to or greater than the weight of the medicine, said core having a water-insoluble, water-permeable coating surrounding said core, said coating containing particulate, water-soluble, pore-forming material dispersed therein and an agent to increase the water permeability of the coating dispersed therein.

6. The composition of claim 5 wherein the water permability increasing agent is polyethylene glycol.
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