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|Title:||Medical bandage for administering vasodilator drug|
|Abstract:||A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.|
|Inventor(s):||Gale; Robert M. (Mountain View, CA)|
|Assignee:||ALZA Corporation (Palo Alto, CA)|
|Filing Date:||Jun 09, 1986|
|Claims:||1. A medical bandage for the administration of a drug to the skin, the medical bandage consisting essentially of: |
(a) a backing member that is substantially impermeable to the passage of drug, the backing member consisting essentially of polyethylene, aluminized polyethylene-terephthalate, and ethylene-vinyl actate compolymer;
(b) a reservoir in contact with the backing member, the reservoir consisting essentially of a silicone, from about 0.1 to about 25% of silicon dioxide, and from 0.1 to about 70% of a dosage amount of a vasodilator drug having a member selected from the group consisting of ONO and ONO.sub.2 ; and,
(c) a membrane positioned opposite the backing member and in contact with the reservoir for releasing drug from the medical bandage, said membrane consisting essentially of ethylene-vinyl acetate copolymer and in contact with the backing member to form the medical bandage.
2. The medical bandage for the administration of the drug to the skin according to claim 1, wherein the membrane and the backing member contact along their perimeters in a fluid tight arrangement to provide the medical bandage.
3. The medical bandage for the administration of the drug to the skin according to claim 1, wherein an adhesive is in contact with the membrane.
4. The medical bandage for the administration of the drug to the skin according to claim 1, wherein the vasodilator drug is nitroglycerin.
5. The medical bandage for the administration of the drug to the skin according to claim 1, wherein the membrane releases the drug at the rate of about 10 to 2000 .mu.g/hr from the medical bandage.
6. The medical bandage for the administration of the drug to the skin according to claim 1, wherein the medical bandage releases drug to a skin that exhibits a flux of about 70 to 90 .mu.g/cm.sup.2 for the drug.
7. The medical bandage for the administration of the drug to the skin according to claim 1, wherein the backing member consists essentially of a lamina of polyethlyene, a lamina of aluminum vapor deposited on polythylene-terephthalate, and a lamina of ethylene-vinyl acetate copolymer.
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