.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 4,644,007

« Back to Dashboard

Details for Patent: 4,644,007

Title: 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods
Abstract:3-chloro-4-(4,5-dihydro-1H-imidazao-2-yl)-amino-5-alkylbenzoic acid, its pharmaceutically acceptable metal salts and esters are useful in treating glaucoma by virtue of the effect in lowering intraocular pressure when administered systemically or topically to the eye. Also disclosed are processes for preparing the compounds, pharmaceutical compositions comprising the disclosed compounds; and methods of treatment comprising administering said compositions when a lowering of intraocular pressure is indicated.
Inventor(s): York, Jr.; Billie M. (Fort Worth, TX)
Assignee: Alcon Laboratories, Inc. (Fort Worth, TX)
Filing Date:Jul 15, 1985
Application Number:06/755,373
Claims:1. An ophthalmic pharmaceutical composition comprising an intraocular pressure lowering amount of a compound of the following general formula: ##STR7## wherein R is methyl or ethyl, and the pharmaceutically acceptable salts and esters thereof, and a pharmaceutically acceptable vehicle therefor.

2. An ophthalmic pharmaceutical composition according to claim 1 wherein the compound is of the following general formula: ##STR8## wherein R is methyl or ethyl, the alkali metal salts, the alkaline earth metal salts, the pharmaceutically acceptable esters and the pharmaceutically acceptable acid addition salts thereof, wherein said esters are esters of the --COOH group wherein the ester is of the formula --COOR', wherein R' is selected from the group consisting of lower alkyl of up to 6 carbon atoms, lower cycloalkyl of 3 to 7 carbon atoms, lower cycloalkylalkyl of 4 to 8 carbon atoms, alkynyl of 2 to 7 carbon atoms, aryl of 5 to 13 carbon atoms, including aryl substituted by up to 5 substituents selected from the group consisting of halogen, methoxy, and lower alkyl; and arylalkyl of 6 to 14 carbon atoms.

3. A composition according to claim 2 wherein the compound is of the following formula: ##STR9## wherein R is methyl or ethyl, R' is hydrogen, alkali metal, methyl, ethyl, isopropyl, n-propyl, t-butyl, cyclopropyl, or cyclopropylmethyl and the pharmaceutically acceptable acid addition salts thereof.

4. A composition according to claim 2 wherein the compound is of the following formula: ##STR10##

5. A composition according to claim 2 wherein the compound is of the following formula: ##STR11##

6. A composition according to claim 2 wherein the compound is of the following formula: ##STR12##

7. A composition according to claim 2 wherein the compound is of the following formula: ##STR13##

8. A composition according to claim 2 wherein the compound is of the following formula: ##STR14##

9. A composition according to claim 2 wherein the compound is of the following formula: ##STR15##

10. A composition according to claim 2 wherein the compound is of the following formula: ##STR16##

11. A composition according to claim 1 wherein the compound is present in the vehicle in an amount of 0.1 to 2.0 wt.% and at a pH of 4.5 to 8.0.

12. A method of lowering intraocular pressure comprising administering to the eye a therapeutically effective amount of a composition of claim 1.

13. A method of lowering intraocular pressure comprising administering to the eye a therapeutically effective amount of a composition of claim 2.

14. A method of lowering intraocular pressure according to claim 12 wherein the composition is administered topically.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc