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Details for Patent: 4,607,025

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Details for Patent: 4,607,025

Title: Disaccharides having a glucosamine and uronic acid structure, and biological applications thereof
Abstract:1,4 .alpha. disaccharides of formula: ##STR1## with Z representing a nitrogenous functional group, M hydrogen or a sulphate or acetyl group, R an alkyl radical of 1 to 4 carbon atoms and A a functional group such as an acid group, or a derivative.
Inventor(s): Petitou; Maurice (Paris, FR), Sinay; Pierre (Orleans, FR), Choay; Jean (Paris, FR), Lormeau; Jean-Claude (Maromme, FR)
Assignee: Choay S.A. (Paris, FR)
Filing Date:Dec 20, 1982
Application Number:06/451,615
Claims:1. A disaccharide of the formula ##STR8## wherein M is hydrogen, --SO.sub.3 Na or acetyl; Z is --SO.sub.3 Na or acetyl and R.sub.1 is hydrogen, methyl or sodium.

2. The disaccharide of claim 1 wherein M is --SO.sub.3 Na and R.sub.1 is sodium.

3. The disaccharide of claim 1 wherein Z is --SO.sub.3 Na, M is --SO.sub.3 Na and R.sub.1 is Na.

4. A disaccharide of the formula ##STR9## wherein Z is --N.sub.3, --NH.sub.2, --NHCOCH.sub.3 or --NHSO.sub.3 M.sub.2 ;

R is alkyl from 1 to 4 carbons or aryl from 6 to 7 carbons;

R.sub.1 is hydrogen, alkyl from 1 to 4 carbons or a metal;

R.sub.2 is hydrogen or benzyl;

M is hydrogen, acetyl or --SO.sub.3 M.sub.1 ; and

M.sub.1 and M.sub.2 may be the same or different and are an alkali metal cation.

5. The compound of claim 4 wherein M is hydrogen, --SO.sub.3 Na, or acetyl, Z is --N.sub.3, R.sub.2 is benzyl, and R and R.sub.1 are methyl.

6. The compound of claim 4 wherein M is --SO.sub.3 Na, Z is --NH.sub.2, R.sub.2 is hydrogen and R and R.sub.1 are methyl.

7. The compound of claim 4 wherein M is --SO.sub.3 Na, Z is --NHCOCH.sub.3 or --NHSO.sub.3 Na, R is methyl, R.sub.1 is methyl or sodium and R.sub.2 is hydrogen.

8. The compound of claim 7 wherein Z is --NHCOCH.sub.3 and R.sub.1 is methyl.

9. The compound of claim 7 wherein Z is --NHCOCH.sub.3 and R.sub.1 is sodium.

10. The compound of claim 7 wherein Z is --NHSO.sub.3 Na and R.sub.1 is methyl.

11. A biological composition which comprises a biologically acceptable carrier and in a therapeutically effective amount, a disaccharide of claims 1, 2, 4, 5, 6, 7, 8, 9 or 10.

12. A therapeutic method for controlling thrombosis in a patient which comprises administering to said patient the therapeutic composition of claim 11 and thereby controlling thrombosis.
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