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|Title:||Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives|
|Abstract:||The administration of sex hormones, particularly testosteorne, progesterone and estradiol in the form of their complexes or inclusions with specific derivatives of cyclodextrins by the sublingual or buccal route results in effective transfer of these hormones into the systemic circulation, followed by only gradual elimination. To be effective in the above mode of administration, the derivatives of cyclodextrins must carry one or several substituents, each containing one or several hydroxy groups. Specially preferred are the following complexes: hydroxypropylbeta-cyclodextrin and poly-beta-cyclodextrin.|
|Inventor(s):||Pitha; Josef (Baltimore, MD)|
|Assignee:||The United States of America as represented by the Secretary, Dept. of (Washington, DC)|
|Filing Date:||Apr 25, 1984|
|Claims:||1. A method of treating a human by sex hormone addition which comprises injecting by the buccal route a regimen of 0.1-25 mg per diem of a compound consisting of testosterone, progesterone, and estradiol as an inclusion complex with poly-.beta.-cyclodextrin or hydroxypropyl-.beta.-cyclodextrin. |
2. The method of claim 1 wherein poly-.beta.-cyclodextrin is utilized.
3. The method of claim 1 wherein hydroxypropyl-.beta.-cyclodextrin is utilized.
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