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|Title:||Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones|
|Abstract:||A series of pharmaceutical compositions which contain 4-aminoalkyl-2(3H)-indolones has been demonstrated to have D.sub.2 -agonist activity useful for treating congestive heart failure and hypertension. A representative ingredient of the compositions is 4-di-n-propylaminoethyl-2(3H)-indolone or a salt thereof.|
|Inventor(s):||Gallagher, Jr.; Gregory (Jeffersonville, PA)|
|Assignee:||SmithKline Beckman Corporation (Philadelphia, PA)|
|Filing Date:||Apr 05, 1984|
|Claims:||1. The method of treating hypertension, angina pectoris, congestive heart failure or kidney dysfunction by inducing D.sub.2 -receptor agonist activity comprising administering orally, rectally or parenterally to a patient subject to one of these abnormal conditions a nontoxic, active therefor quantity of a compound of the structural formula; ##STR4## in which: R is, each, hydrogen, lower alkyl, benzyl, allyl, phenethyl or 4-hydroxyphenethyl; |
R.sup.1, R.sup.2 and R.sup.3 are each hydrogen or C.sub.1-4 -lower alkyl; and
n is 1, 2 or 3; or a pharmaceutically acceptable acid addition salt thereof, in dosage unit form, combined with a pharmaceutical carrier.
2. The method of claim 1 in which the compound is 4-(2-di-n-propylaminoethyl)-2(3H)-indolone or a pharmaceutically active acid addition salt thereof.
3. The method of claim 1 in which the compound is 4-(2-di-n-propylaminoethyl)-2(3H)-indolone hydrochloride.
4. The method of claim 8 in which the compound is 4-[N-n-propyl-N-(4-hydroxyphenethyl)-2-aminoethyl]-2-(3H)-indolone or a pharmaceutically acceptable, acid addition salt thereof.
5. The method of claim 1 in which the compound is administered orally or parenterally from 1 to 5 times daily in the form of a dosage unit containing a quantity of the compound selected from the range of 50-500 mg.
6. The method of claim 5 in which a quantity selected from 75-250 mg per dosage unit is administered from 1-5 times daily.
7. The method of claim 1 in which R.sup.1, R.sup.2 and R.sup.3 are each hydrogen.
8. The method of claim 6 in which the patient is hypertensive.
9. The method of claim 6 in which the patient has angina pectoris.
10. The method of claim 6 in which the patient has the symptoms of congestive heart failure.
11. 4-[N-n-Propyl-N-(4-hydroxyphenethyl)-2-aminoethyl]-2(3H)-indolone or a pharmaceutically acceptable, acid addition salt thereof.
12. The compound of claim 11 as the hydrochloride salt.
13. The compound of claim 11 as the methanesulfonic acid salt.
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