Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Argus Health
Johnson and Johnson

Generated: May 22, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,567,271

« Back to Dashboard

Title: Benzoxadiazoles and benzothiadiazoles
Abstract:Compounds of formula I, ##STR1## wherein X is oxygen or sulphur, and R.sub.1 -R.sub.6 are various substituents. The compounds are useful for treating coronary insufficiency, intermittent claudication, cerebrovascular insults, spasms in muscles and hypertension.
Inventor(s): Neumann; Peter (Berne, CH)
Assignee: Sandoz Ltd. (Basle, CH)
Filing Date:May 29, 1984
Application Number:06/614,650
Claims:1. A compound having the formula ##STR93## wherein R.sub.1 ' is hydrogen or C.sub.1-6 alkyl;

R.sub.2 ' and R.sub.5 ', independently, are hydrogen or C.sub.1-6 alkyl;

R.sub.3 ' and R.sub.4 ', independently, are COOR.sub.7 ' or ##STR94## each R.sub.7 ', independently, is C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.7-10 phenylalkyl, C.sub.3-6 alkoxyalkyl, C.sub.2-6 -hydroxyalkyl or C.sub.4-8 hydroxyalkoxyalkyl;

A is C.sub.1-6 alkylene;

each R.sub.8 ' and R.sub.9 ', independently, is C.sub.1-6 alkyl or C.sub.7-10 phenylalkyl; and

X is oxygen or sulphur, with the proviso that at least one of R.sub.3 ' and R.sub.4 ' is COOR.sub.7 '

where R.sub.7 ' is C.sub.2-6 hydroxyalkyl or C.sub.4-8 hydroxyalkoxyalkyl, or a pharmaceutically acceptable acid addition salt of a basic compound of the above formula.

2. A compound of claim 1 wherein R.sub.7 ' is C.sub.2-6 hydroxyalkyl.

3. A compound of claim 1 wherein R.sub.7 ' is C.sub.4-8 hydroxyalkoxyalkyl.

4. A compound of claim 1 wherein R.sub.1 ' is hydrogen.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Farmers Insurance
US Army

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.