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Details for Patent: 4,567,271

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Details for Patent: 4,567,271

Title: Benzoxadiazoles and benzothiadiazoles
Abstract:Compounds of formula I, ##STR1## wherein X is oxygen or sulphur, and R.sub.1 -R.sub.6 are various substituents. The compounds are useful for treating coronary insufficiency, intermittent claudication, cerebrovascular insults, spasms in muscles and hypertension.
Inventor(s): Neumann; Peter (Berne, CH)
Assignee: Sandoz Ltd. (Basle, CH)
Filing Date:May 29, 1984
Application Number:06/614,650
Claims:1. A compound having the formula ##STR93## wherein R.sub.1 ' is hydrogen or C.sub.1-6 alkyl;

R.sub.2 ' and R.sub.5 ', independently, are hydrogen or C.sub.1-6 alkyl;

R.sub.3 ' and R.sub.4 ', independently, are COOR.sub.7 ' or ##STR94## each R.sub.7 ', independently, is C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.7-10 phenylalkyl, C.sub.3-6 alkoxyalkyl, C.sub.2-6 -hydroxyalkyl or C.sub.4-8 hydroxyalkoxyalkyl;

A is C.sub.1-6 alkylene;

each R.sub.8 ' and R.sub.9 ', independently, is C.sub.1-6 alkyl or C.sub.7-10 phenylalkyl; and

X is oxygen or sulphur, with the proviso that at least one of R.sub.3 ' and R.sub.4 ' is COOR.sub.7 '

where R.sub.7 ' is C.sub.2-6 hydroxyalkyl or C.sub.4-8 hydroxyalkoxyalkyl, or a pharmaceutically acceptable acid addition salt of a basic compound of the above formula.

2. A compound of claim 1 wherein R.sub.7 ' is C.sub.2-6 hydroxyalkyl.

3. A compound of claim 1 wherein R.sub.7 ' is C.sub.4-8 hydroxyalkoxyalkyl.

4. A compound of claim 1 wherein R.sub.1 ' is hydrogen.
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