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Serving leading biopharmaceutical companies globally:

Queensland Health
Daiichi Sankyo
Boehringer Ingelheim
Farmers Insurance

Generated: December 16, 2017

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Title: 6-[3-Amino-1-(4-tolyl)prop-1E-enyl]pyridine-2-carboxylic acid derivatives having antihistaminic activity
Abstract:This disclosure describes compounds of Formula I. ##STR1## (including their pharmaceutically acceptable salts and esters) which have potent antihistamine activity which are substantially free from sedative effects.
Inventor(s): Findlay; John W. A. (Chapel Hill, NC), Coker; Geoffrey G. (Bromley, GB2)
Filing Date:Feb 01, 1983
Application Number:06/462,874
Claims:1. A compound of formula (I), ##STR12## or a straight or branched lower alkyl (1-4 carbon atoms) ester, or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a bond; R.sup.2 and R.sup.3 are the same or different and can be hydrogen, C.sub.1-4 alkyl or taken together with the nitrogen together with the nitrogen to which they are attached form a nitrogen containing heterocyclic ring having four to six ring members; R.sup.4 is hydrogen, halogen, C.sub.1-4 alkoxy or C.sub.1-4 alkyl optionally substituted by one to three halogen atoms.

2. 6-[3-pyrrolidino-1-(4-tolyl)prop-1E-enyl]pyridine-2-carboxylic acid.

3. A compound of claim 1 as the hydrochloride salt.

4. A pharmaceutically acceptable salt of 6-[3-pyrrolidino-1-(4-tolyl)prop-1E-enyl]pyridine-2-carboxylic acid.
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Serving leading biopharmaceutical companies globally:

US Department of Justice
Federal Trade Commission
Daiichi Sankyo
Johnson and Johnson
Boehringer Ingelheim

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