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|Title:||6-[3-Amino-1-(4-tolyl)prop-1E-enyl]pyridine-2-carboxylic acid derivatives having antihistaminic activity|
|Abstract:||This disclosure describes compounds of Formula I. ##STR1## (including their pharmaceutically acceptable salts and esters) which have potent antihistamine activity which are substantially free from sedative effects.|
|Inventor(s):||Findlay; John W. A. (Chapel Hill, NC), Coker; Geoffrey G. (Bromley, GB2)|
|Filing Date:||Feb 01, 1983|
|Claims:||1. A compound of formula (I), ##STR12## or a straight or branched lower alkyl (1-4 carbon atoms) ester, or a pharmaceutically acceptable salt thereof; wherein R.sup.1 is a bond; R.sup.2 and R.sup.3 are the same or different and can be hydrogen, C.sub.1-4 alkyl or taken together with the nitrogen together with the nitrogen to which they are attached form a nitrogen containing heterocyclic ring having four to six ring members; R.sup.4 is hydrogen, halogen, C.sub.1-4 alkoxy or C.sub.1-4 alkyl optionally substituted by one to three halogen atoms. |
2. 6-[3-pyrrolidino-1-(4-tolyl)prop-1E-enyl]pyridine-2-carboxylic acid.
3. A compound of claim 1 as the hydrochloride salt.
4. A pharmaceutically acceptable salt of 6-[3-pyrrolidino-1-(4-tolyl)prop-1E-enyl]pyridine-2-carboxylic acid.