.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 4,558,156

« Back to Dashboard

Details for Patent: 4,558,156

Title: Sulfamoyl-substituted phenethylamine derivatives
Abstract:Novel sulfamoyl-substituted phenethylamine derivatives which exhibit .alpha.-adrenergic blocking action and are useful as an antihypertensive agent and an agent for the treatment of congestive heart failure.
Inventor(s): Imai; Kazuo (Saitama, JP), Niigata; Kunihiro (Saitama, JP), Fujikura; Takashi (Saitama, JP), Hashimoto; Shinichi (Chiba, JP), Takenaka; Toichi (Tokyo, JP)
Assignee: Yamanouchi Pharmaceutical Co., Ltd. (Tokyo, JP)
Filing Date:Jul 18, 1984
Application Number:06/632,258
Claims:1. Sulfamoyl-substituted phenethylamine derivatives represented by the general formula ##STR78## wherein R.sub.1 represents an amino group or a mono- or di-lower alkylamino group; R.sub.2 represents a hydroxyl group, a lower alkyl group, or a lower alkoxy group; R.sub.3 represents a halogen atom, a phenylthio group, or a phenylsulfinyl group; R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, and R.sub.9 each represents a hydrogen atom or a lower alkyl group; R.sub.10 represents hydrogen atom, a lower alkyl group, or a lower alkoxy group; and Y represents an oxygen atom or a methylene group; said Y being, however, an oxygen atom when R.sub.2 is a hydroxyl group and the salts thereof.

2. The compound of claim 1 wherein R.sub.3 is a halogen atom.

3. The compound of claim 1 wherein R.sub.3 is a phenylthio group or a phenylsulfinyl group.

4. The compound of claim 1 wherein the salt is hydrochloride.

5. The compound of claim 1 which is 5-{1-chloro-2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2-methoxybenz enesulfonamide or the hydrochloride salt thereof.

6. The compound of claim 1 which is 5-{1-chloro-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfon amide or the hydrochloride salt thereof.

7. The compound of claim 1 which is 5-{1-chloro-2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl}-2-methoxyben zenesulfonamide or the hydrochloride salt thereof.

8. The compound of claim 1 which is 5-{1-iodo-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-2methylbenzenesulfona mide or the hydrochloride salt thereof.

9. The compound of claim 1 which is 5-{2-[2-(2methoxyphenoxy)ethylamino]-1-phenylthioethyl}-2-methylbenzenesul fonamide or the hydrochloride salt thereof.

10. The compound of claim 1 which is 5-{2-[2-(2-methoxyphenoxy)ethylamino]-1-phenylsulfinylethyl}-2-methylbenze nesulfonamide.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc