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Details for Patent: 4,558,156

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Details for Patent: 4,558,156

Title: Sulfamoyl-substituted phenethylamine derivatives
Abstract:Novel sulfamoyl-substituted phenethylamine derivatives which exhibit .alpha.-adrenergic blocking action and are useful as an antihypertensive agent and an agent for the treatment of congestive heart failure.
Inventor(s): Imai; Kazuo (Saitama, JP), Niigata; Kunihiro (Saitama, JP), Fujikura; Takashi (Saitama, JP), Hashimoto; Shinichi (Chiba, JP), Takenaka; Toichi (Tokyo, JP)
Assignee: Yamanouchi Pharmaceutical Co., Ltd. (Tokyo, JP)
Filing Date:Jul 18, 1984
Application Number:06/632,258
Claims:1. Sulfamoyl-substituted phenethylamine derivatives represented by the general formula ##STR78## wherein R.sub.1 represents an amino group or a mono- or di-lower alkylamino group; R.sub.2 represents a hydroxyl group, a lower alkyl group, or a lower alkoxy group; R.sub.3 represents a halogen atom, a phenylthio group, or a phenylsulfinyl group; R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, and R.sub.9 each represents a hydrogen atom or a lower alkyl group; R.sub.10 represents hydrogen atom, a lower alkyl group, or a lower alkoxy group; and Y represents an oxygen atom or a methylene group; said Y being, however, an oxygen atom when R.sub.2 is a hydroxyl group and the salts thereof.

2. The compound of claim 1 wherein R.sub.3 is a halogen atom.

3. The compound of claim 1 wherein R.sub.3 is a phenylthio group or a phenylsulfinyl group.

4. The compound of claim 1 wherein the salt is hydrochloride.

5. The compound of claim 1 which is 5-{1-chloro-2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2-methoxybenz enesulfonamide or the hydrochloride salt thereof.

6. The compound of claim 1 which is 5-{1-chloro-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfon amide or the hydrochloride salt thereof.

7. The compound of claim 1 which is 5-{1-chloro-2-[2-(2-methoxyphenoxy)ethylamino]-2-methylethyl}-2-methoxyben zenesulfonamide or the hydrochloride salt thereof.

8. The compound of claim 1 which is 5-{1-iodo-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-2methylbenzenesulfona mide or the hydrochloride salt thereof.

9. The compound of claim 1 which is 5-{2-[2-(2methoxyphenoxy)ethylamino]-1-phenylthioethyl}-2-methylbenzenesul fonamide or the hydrochloride salt thereof.

10. The compound of claim 1 which is 5-{2-[2-(2-methoxyphenoxy)ethylamino]-1-phenylsulfinylethyl}-2-methylbenze nesulfonamide.
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