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|Title:||Process for preparing osmotic device|
|Abstract:||An osmotic delivery system is disclosed for dispensing a useful agent. The system comprises a semipermeable wall surrounding a compartment housing the agent. The wall comprises a cellulose ether, an organic solvent soluble polymer, and optionally an aqueous soluble polymer. A passageway in the wall connects the interior of the system with the exterior for dispensing an agent from the system.|
|Inventor(s):||Edgren; David (El Granada, CA)|
|Assignee:||Alza Corporation (Palo Alto, CA)|
|Filing Date:||Feb 01, 1985|
|Claims:||1. A process for making an osmotic delivery system for delivering a beneficial drug to an environment of use, said process comprising: |
(a) compressing a drug formulation into a solid mass of drug;
(b) coating the solid mass of drug with a wall-forming composition comprising (1) ethyl cellulose (2) a polyhydroxy polymer member selected from the group consisting of hydroxypropyl cellulose, hydroxypropyl methylcellulose, and hydroxyethyl cellulose, and (3) a carboxypolymer selected from the group consisting of carboxypolymethylene, poly(methylvinylether maleic anhydride), ethylene-acrylic acid copolymer, ethylene maleic acid anhydride copolymer, and methacrylic acid-ethylacrylic acid copolymer;
(c) reacting the polyhydroxy polymer and the carboxypolymer by heating the coated solid mass of drug to a temperature sufficient to cause the polyhydroxy polymer and the carboxypolymer to react and from with the ethyl cellulose a wall surrounding the solid mass of drug;
(d) cooling the wall surrounded solid mass of drug to room temperature; and,
(e) drilling a passageway through the wall for delivering the drug formulation from the delivery system.
2. The process for making an osmotic delivery system according to claim 1, wherein the wall-forming composition comprises 20 to 90 weight percent ethyl cellulose, 10 to 50 weight percent polyhydroxy polymer and 10 to 80 weight percent carboxypolymer per 100 weight percent wall forming composition.
3. The process for making an osmotic delivery system according to claim 1, wherein the polyhydroxy polymer and the carboxypolymer are reacted at a temperature of 60.degree. to 80.degree. C.
4. The process for making an osmotic delivery system according to claim 1, wherein the polyhydroxy polymer and the carboxypolymer are reacted at a temperature of 60.degree. to 80.degree. C. for 1 to 7 days.
5. The process for making an osmotic delivery system according to claim 1, wherein the reaction occurs in the wall.
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