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|Title:||N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids|
|Abstract:||N-substituted amino acids are described which when coupled with 1,2,3,4-tetrahydroisoquinolines result in substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids as anti-hypertensive agents. The novel intermediates are in turn prepared by reacting an amino acid such as alanine with 2-bromo-4-phenyl butanoic acid or an ester thereof.|
|Inventor(s):||Hoefle; Milton L. (Ann Arbor, MI), Klutchko; Sylvestor (Ann Arbor, MI)|
|Assignee:||Warner-Lambert Company (Morris Plains, NJ)|
|Filing Date:||Jun 08, 1982|
|Claims:||1. The N-substituted amino acid according to the formula ##STR5## and salts thereof. |
2. The N-substituted amino acid according to the formula ##STR6## and the hydrochloride salt thereof.
3. The N-substituted amino acid according to claim 2 designated ethyl.alpha.-[(1-carboxyethyl)amino]-benzenebutanoate hydrochloride (S,S).
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