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Details for Patent: 4,532,342

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Details for Patent: 4,532,342

Title: N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
Abstract:N-substituted amino acids are described which when coupled with 1,2,3,4-tetrahydroisoquinolines result in substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids as anti-hypertensive agents. The novel intermediates are in turn prepared by reacting an amino acid such as alanine with 2-bromo-4-phenyl butanoic acid or an ester thereof.
Inventor(s): Hoefle; Milton L. (Ann Arbor, MI), Klutchko; Sylvestor (Ann Arbor, MI)
Assignee: Warner-Lambert Company (Morris Plains, NJ)
Filing Date:Jun 08, 1982
Application Number:06/386,375
Claims:1. The N-substituted amino acid according to the formula ##STR5## and salts thereof.

2. The N-substituted amino acid according to the formula ##STR6## and the hydrochloride salt thereof.

3. The N-substituted amino acid according to claim 2 designated ethyl.alpha.-[(1-carboxyethyl)amino]-benzenebutanoate hydrochloride (S,S).
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