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Generated: February 20, 2018

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Title: 1,4-Bis (substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
Abstract:This disclosure describes symmetrical 1,4-bis (substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors.
Inventor(s): Murdock; Keith C. (Pearl River, NY), Durr; Frederick E. (Ridgewood, NJ)
Assignee: American Cyanamid Company (Stamford, CT)
Filing Date:Oct 23, 1979
Application Number:06/087,354
Claims:1. A compound selected from the group consisting of 1,4-bis[(2-aminoethyl)amino]-5,8-dihydroxyanthraquinone, the leuco base and tautomer thereof, and the pharmacologically acceptable acid-addition salts thereof.

2. The aromatic free base according to claim 1.

3. The leuco free base according to claim 1.

4. The acid-addition salt of the aromatic base according to claim 1 wherein the acid is sulfuric acid.

5. The acid-addition salt of the leuco base according to claim 1 wherein the acid is phosphoric acid.

6. The acid-addition salt of the aromatic base according to claim 1 wherein the acid is hydrochloric acid.

7. The acid-addition salt of the leuco base according to claim 1 wherein the acid is hydrobromic acid.

8. The acid-addition salt of the aromatic base according to claim 1 wherein the acid is sulfamic acid.

9. The acid-addition salt of the leuco base according to claim 1 wherein the acid is citric acid.

10. The acid-addition salt of the aromatic base according to claim 1 wherein the acid is lactic acid.

11. The acid-addition salt of the leuco base according to claim 1 wherein the acid is malic acid.

12. The acid-addition salt of the aromatic base according to claim 1 wherein the acid is succinic acid.

13. The acid-addition salt of the leuco base according to claim 1 wherein the acid is tartaric acid.

14. The acid-addition salt of the aromatic base according to claim 1 wherein the acid is acetic acid.

15. The acid-addition salt of the leuco base according to claim 1 wherein the acid is benzoic acid.

16. The acid-addition salt of the aromatic base according to claim 1 wherein the acid is gluconic acid.

17. The acid-addition salt of the leuco base according to claim 1 wherein the acid is ascorbic acid.
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