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Details for Patent: 4,526,988

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Details for Patent: 4,526,988

Title: Difluoro antivirals and intermediate therefor
Abstract:A 2,2-difluoro-2-desoxycarbohydrate is used to prepare antiviral nucleosides.
Inventor(s): Hertel; Larry W. (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Filing Date:Mar 10, 1983
Application Number:06/473,883
Claims:1. A process for preparing a lactone of the formula ##STR11## which process comprises hydrolyzing, under very mild conditions, an alkyl 3-dioxolanyl-2,2-difluoro-3-hydroxypropionate of the formula ##STR12## wherein R.sup.4 and R.sup.5 are independently C.sub.1 -C.sub.3 alkyl.

2. A process of claim 1 wherein the propionate is a compound wherein R.sup.4 and R.sup.5 are methyl groups.

3. A process of claim 2 wherein the hydrolysis reagent is a mildly acidic ion exchange resin.
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