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Generated: August 20, 2017
| Title: | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1H-imida zoles and 1H-1,2,4-triazoles |
| Abstract: | Novel heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazol es and 1H-1,2,4-triazoles, useful as intermediates and as antifungal and antibacterial agents. |
| Inventor(s): | Heeres; Jan (Vosselaar, BE), Backx; Leo J. J. (Arendonk, BE) |
| Assignee: | Janssen Pharmaceutica N.V. (Beerse, BE) |
| Filing Date: | Sep 28, 1982 |
| Application Number: | 06/425,370 |
| Claims: | 1. A chemical compound having the formula ##STR68## and the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein: Q is a member selected from the group consisting of CH and N; Ar is a member selected from the group consisting of phenyl, thienyl, halothienyl and substituted phenyl, said substituted phenyl having from 1 to 3 substituents each independently selected from the group consisting of halo, lower alkyl, lower alkyloxy and trifluoromethyl. 2. A chemical compound selected from the group consisting of cis-4-[4-[4-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl-methyl)-1,3-dioxol an-4-ylmethoxy]phenyl]-1-piperazinyl]benzenamine and the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof. 3. A chemical compound selected from the group consisting of cis-4-[4-[4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl-methyl)-1,3-d ioxolan-4-ylmethoxy]phenyl]-1-piperazinyl]benzenamine and the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof. |
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