Deep knowledge on
small-molecule drugs and
the 110,000 global patents
Drug patents …
… from Kazakhstan to Kalamazoo
Anticipate generic drug launch
Find generic entry opportunities
Proactively manage your pharmacy inventory
Manage your formulary budget
|Title:||Substituted aromatic compounds|
|Abstract:||The present invention provides compounds of the formula (III): ##STR1## or an acid addition salt thereof, wherein R.sup.6 is chlorine, bromine, iodine, C.sub.1-4 alkyl or trifluoromethyl, or R.sup.6 and R.sup.7 form a --CH.dbd.CH--CH.dbd.CH--group optionally substituted by a halogen atom or a C.sub.1-4 alkyl or trifluoromethyl group, R.sup.8 is hydrogen, bromine, iodine, C.sub.1-4 alkyl or trifluoromethyl, R.sup.9 is hydrogen, halogen, C.sub.1-4 alkyl or trifluoromethyl, R.sup.10 is hydrogen, methyl or fluorine and R.sup.11 is amino, C.sub.1-10 acylamino or di-substituted aminomethyleneamino provided that, at most, only two of R.sup.7 -R.sup.10 are other than hydrogen and that R.sup.7 -R.sup.10 are not all hydrogen when R.sup.6 is chlorine. Also provided are pharmaceutical compositions containing compounds of the formula (III), the first medical use of compounds of the formula (III), a process for preparing such compounds and intermediates through which this process proceeds.|
|Inventor(s):||Baxter; Martin G. (Wilmington, Dartford, Kent, GB2), Elphick; Albert R. (Lee, London, SE. 12, GB2), Miller; Alistair A. (Tonbridge, Kent, GB2), Sawyer; David A. (Hayes, Kent, GB2)|
|Filing Date:||Oct 05, 1981|
|Claims:||1. A compound of the formula (IV): ##STR10## wherein R.sup.6 is a chlorine or bromine atom or is linked to R.sup.7 to form a CH.dbd.CH--CH.dbd.CH-- group, and R.sup.7 and R.sup.9 are hydrogen, chlorine or bromine provided that R.sup.7 and R.sup.9 cannot both be hydrogen. |
2. A compound of claim 1 wherein R.sup.6 is chlorine and R.sup.7 and R.sup.9 cannot both be hydrogen.
3. A compound of claim 1 wherein R.sup.6 and R.sup.7 are chlorine and R.sup.9 is hydrogen.