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Details for Patent: 4,456,552

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Details for Patent: 4,456,552

Title: 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
Abstract:This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors.
Inventor(s): Murdock; Keith C. (Pearl River, NY), Durr; Frederick E. (Ridgewood, NJ)
Assignee: American Cyanamid Company (Stamford, CT)
Filing Date:Mar 02, 1981
Application Number:06/239,939
Claims:1. A compound selected from the group consisting of 1,4-bis[2-(2-aminoethylamino)ethylamino]-5,8-dihydroxyanthaquinone, the leuco base and tautomer thereof and the pharmacologically acceptable acid-addition salts thereof.

2. A compound selected from the group consisting of 1,4-bis[2-(2-methylaminoethylamino)ethylamino]-5,8-dihydroxyanthraquinone, the leuco base and tautomer thereof and the pharmacologically acceptable acid-addition salts thereof.

3. A compound selected from the group consisting of 1,4-bis[2-(2-dimethylaminoethylamino)ethylamino]-5,8-dihydroxyanthraquinon e, the leuco base and tautomer thereof and the pharmacologically acceptable acid-addition salts thereof.

4. A compound selected from the group consisting of 1,4-bis[2-(2,3-dihydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone , the leuco base and tautomer thereof and the pharmacologically acceptable acid-addition salts thereof.

5. A compound selected from the group consisting of 1,4-bis[2-(N-(.beta.-hydroxyethyl)trifluoroacetamido)ethylamino]-5,8-dihyd roxyanthraquinone, the leuco base and tautomer thereof and the pharmacologically acceptable acid-addition salts thereof.
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