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Serving hundreds of leading biopharmaceutical companies globally:

Harvard Business School
US Army
Johnson and Johnson
Boehringer Ingelheim

Generated: March 21, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,448,979

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Title: ML-236B Derivatives
Abstract:Compounds of formula (I): ##STR1## (wherein R represents a group of formula ##STR2## and the corresponding ring-closed lactones, salts (especially alkali metal salts) and esters (especially C.sub.1 -C.sub.5 alkyl esters) thereof may be prepared by subjecting ML-236B, or ML-236B carboxylic acid or a salt or ester thereof to enzymatic hydroxylation, which may be effected by means of microorganisms of the genera Mucor, Rhizopus, Zygorynchus, Circinella, Actinomucor, Gongronella, Phycomyces, Martierella, Pycnoporus, Rhizoctonia, Absidia, Cunninghamella, Syncephalastrum and Streptomyces, or cell-free, enzyme-containing extracts from said microorganisms. The compounds are capable of inhibiting biosynthesis of cholesterol and are thus useful in the treatment of hypercholesteraemia.
Inventor(s): Terahara; Akira (Hiromachi, JP), Tanaka; Minoru (Hiromachi, JP)
Assignee: Sankyo Company, Limited (Tokyo, JP)
Filing Date:Feb 24, 1982
Application Number:06/351,975
Claims:1. The compound having the formula (V): ##STR19##

2. The compound having the formula (VII): ##STR20##

3. The compound having the formula (XIII): ##STR21##

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Serving hundreds of leading biopharmaceutical companies globally:

Queensland Health
Harvard Business School
Farmers Insurance
Chinese Patent Office
Fish and Richardson
Federal Trade Commission

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