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QuintilesIMS
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Generated: April 22, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,420,617

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Title: 5(Pyridinyl)pyridin-2-amines
Abstract:5-PY-6-Q-pyridin-2-amines (I) or pharmaceutically acceptable acid-addition salts thereof are useful cardiotonics, where Q is hydrogen or lower-alkyl, and PY is 4-pyridinyl or 4-pyridinyl having one or two lower-alkyl substituents. Their preparation from the corresponding 5-PY-6-Q-2(1H-pyridinones via the corresponding 2-halo-5-PY-6-Q-pyridines is shown.
Inventor(s): Lesher; George Y. (Schodack, NY), Opalka, Jr.; Chester J. (Schodack, NY), Page; Donald F. (East Greenbush, NY)
Assignee: Sterling Drug Inc. (New York, NY)
Filing Date:Jul 06, 1982
Application Number:06/395,737
Claims:1. A 5-PY-6-Q-pyridin-2-amine having the formula ##STR2## or pharmaceutically acceptable acid-addition salt thereof, where Q is hydrogen or lower-alkyl, and PY is 4-pyridinyl or 4-pyridinyl having one or two lower-alkyl substituents.

2. A compound according to claim 1 where Q is hydrogen, methyl or ethyl.

3. A compound according to claim 1 where PY is 4-pyridinyl.

4. 5-(4-Pyridinyl)pyridin-2-amine or pharmaceutically acceptable acid-addition salt thereof.

5. 6-Methyl-5-(4-pyridinyl)pyridin-2-amine or pharmaceutically acceptable acid-addition salt thereof.

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Serving hundreds of leading biopharmaceutical companies globally:

Julphar
Harvard Business School
Farmers Insurance
Chinese Patent Office
Deloitte
McKesson
Dow
QuintilesIMS
US Army

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