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Details for Patent: 4,410,695

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Details for Patent: 4,410,695

Title: 2-Decarboxy-2-tetrazolyl-6-keto-PG compounds
Abstract:The present invention relates to novel 2-decarboxy-2-tetrazolyl-6-keto-PG compounds, which are useful for inducing a variety of prostacyclin-like pharmacological effects. Accordingly, these compounds are useful pharmacological agents for the same purposes for which prostacyclin is employed.
Inventor(s): Axen; Udo F. (Plainwell, MI)
Assignee: The Upjohn Company (Kalamazoo, MI)
Filing Date:Oct 17, 1979
Application Number:06/085,834
Claims:1. A prostacyclin of formula ##STR2## wherein W.sub.1 is .alpha.-OH:.beta.-H, .alpha.-H:.beta.OH, oxo, methylene, .alpha.-H:.beta.-H, .alpha.-CH.sub.2 OH:.beta.-H;

wherein L is

(1) -(CH.sub.2).sub.d -C(R.sub.2).sub.2,

(2) -CH.sub.2 -O-CH.sub.2 -Y-, or

(3) -CH.sub.2 CH.dbd.CH-,

wherein d is zero to 5, R.sub.2 is hydrogen, methyl, or fluoro, being the same or different with the proviso that one R.sub.2 is not methyl when the other is fluoro, and wherein Y is a valence bond, -CH.sub.2 - or -(CH.sub.2).sub.2,

wherein Q is keto, .alpha.-H:.beta.-H, .alpha.-OH:.beta.R.sub.8 or .alpha.-R.sub.8 :.beta.-OH

wherein R.sub.8 is hydrogen or alkyl of one to 4 carbon atoms, inclusive;

wherein R.sub.5 and R.sub.6 hydrogen, alkyl of one to 4 carbon atoms, inclusive, or fluoro, being the same or different, with the proviso that one of R.sub.5 and R.sub.6 is fluoro only when the other is hydrogen or fluoro and the further proviso that neither R.sub.5 nor R.sub.6 is fluoro when Z is oxa (-O-); wherein Z represents an oxa atom (-O-) or C.sub.j H.sub.2j, wherein C.sub.j H.sub.2j is a valence bond or alkylene of one to 9 carbon atoms, inclusive, with one to 6 carbon atoms, inclusive, between CR.sub.5 R.sub.6 - and the phenyl ring; wherein T is alkyl of one to 4 carbon atoms, inclusive, fluoro, chloro, trifluoromethyl, or -OR.sub.7 -, wherein R.sub.7 is alkyl of one to 4 carbon atoms, inclusive, and s is zero or one; and

wherein X is

(1) trans-CH.dbd.CH-,

(2) cis-CH.dbd.CH-,

(3) -C.quadbond.C-, or

(4) -CH.sub.2 CH.sub.2 -;

including the lower alkanoates thereof.
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