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Details for Patent: 4,380,549

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Details for Patent: 4,380,549

Title: Topical treatment of dry skin
Abstract:Preventive as well as therapeutic treatment to alleviate the symptoms of disorders characterized by cracking, flaking, or scaling of the skin consisting of the topical application of a solution, lotion, gel, stick, powder, cream or ointment containing as active ingredients one or more hydroxy acid or its analogue is disclosed. The hydroxyacid and its analogues include free acid, amide, lactone, ester, anhydride, organic or inorganic salt form of hydroxymonocarboxylic acids, hydroxydicarboxylic acids, hydroxytricarboxylic acids and keto acids. The therapeutic composition may include one or more of the compounds present in the total amount of from 0.1 to 20 percent. Topical application to affected areas has been found to ameliorate dry skin conditions.
Inventor(s): Van Scott; Eugene J. (Rydal, PA), Yu; Ruey J. (Ambler, PA)
Assignee:
Filing Date:Mar 23, 1981
Application Number:06/246,364
Claims:1. A method for alleviating the symptoms of dry skin in humans comprising topically applying to involved areas of the human body an effective amount of at least one member selected from the group consisting of:

or a salt thereof with an organic or inorganic alkali, in a pharmaceutically acceptable vehicle.

2. The method of claim 1 wherein said member is present in a concentration of from about 0.1 to 20 percent by weight.

3. The method of claim 1 wherein a plurality of said members are present in a total concentration of no more than about 15 percent by weight.

4. The method of claim 1 wherein said member is present as a salt with at least one base selected from the group consisting of ammonium hydroxide, sodium hydroxide and potassium hydroxide.

5. A method for alleviating the symptoms of dry skin in humans comprising topically applying an effective amount of at least one member selected from the group consisting of: pyruvic acid, benzoylformic acid, .beta.-phenylpyruvic acid, .beta.-hydroxypyruvic acid and .beta.-hydroxypyruvic acid phosphate

or a salt thereof with an organic or inorganic alkali, in a pharmaceutically acceptable vehicle.

6. The method of claim 5 wherein said member is present in a concentration of from about 0.1 to 20 percent by weight.

7. The method of claim 5 wherein a plurality of said members are present in a total concentration of no more than about 15 percent by weight.

8. The method of claim 5 wherein said member is present as a salt with at least one base selected from the group consisting of ammonium hydroxide, sodium hydroxide and potassium hydroxide.

9. A method for alleviating the symptoms of dry skin in humans comprising an effective amount of at least one member selected from the group consisting of: glyceric acid, gluconic acid, glucoheptonic acid, .alpha.-hydroxyisocaproic acid, .alpha.-hydroxyisovaleric acid, atrolactic acid, galatonic acid, isocitric acid, dihydroxymaleic acid, dehydroxytartaric acid, dihydroxyfumaric acid, benzoylformic acid, .beta.-hydroxypyruvic acid, .beta.-hydroxypyruvic acid phosphate, or a salt thereof with an organic or inorganic alkali in a pharmaceutically acceptable vehicle.

10. The method of claim 9 wherein said member is present in a concentration of from about 0.1 to 20 percent by weight.

11. The method of claim 9 wherein a plurality of said members are present in a total concentration of no more than about 15 percent by weight.

12. The method of claim 9 wherein said member is present as a salt with at least one base selected from the group consisting of ammonium hydroxide, sodium hydroxide and potassium hydroxide.
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