Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Abstract:||A process applicable to the preparation of a wide variety of novel polycyclic heterocycles having a newly-formed pyran ring is disclosed. According to the process an aromatic nucleus bearing an ethanol group, for example, 3,4-dimethoxyphenethyl alcohol, is condensed with an aldehyde or ketone or a protected aldehyde or ketone, for example, aminoactaldehyde diethyl acetal, in the presence of an acid catalyst to afford the polycyclic heterocycle, for example, 6,7-dimethoxy-1-isochromanmethylamine. The new heterocycles so formed are useful for preparing derivatives having antiinflammatory, antibacterial or antifungal activities.|
|Inventor(s):||Dobson; Thomas A. (Dollard des Ormeaux, CA), Humber; Leslie G. (Dollard des Ormeaux, CA), Demerson; Christopher A. (St. Laurent, CA), Jirkovsky; Ivo L. (Montreal, CA)|
|Assignee:||American Home Products Corp. (New York, NY)|
|Filing Date:||Jan 07, 1980|
|Claims:||1. A compound of formula 1 ##STR27## wherein R.sup.3 and R.sup.4 each are hydrogen, hydroxyl or lower alkoxy; R.sup.1 is hydrogen, or lower alkyl; and R.sup.2 is 2-thienyl, 2-pyridyl, 3-pyridyl or ##STR28## wherein R.sup.7 and R.sup.8 are the same or different and each represent hydrogen, halo, or hydroxyl with the proviso that when R.sup.7 and R.sup.8 are hydrogen, then R.sup.3 and R.sup.4 are hydroxyl, and when R.sup.7 or R.sup.8 is halo then R.sup.3 and R.sup.4 is hydroxyl or lower alkoxy. |
2. 1-(4-Chlorophenyl)-6,7-dimethoxyisochroman, as claimed in claim 1.
3. 1-(2,6-Dichlorophenyl)-6,7-dimethoxyisochroman, as claimed in claim 1.
4. m-(6,7-Dimethoxyisochroman-1-yl)phenol, as claimed in claim 1.
5. 6,7-Dimethoxy-1-(2-thienyl)isochroman, as claimed in claim 1.
6. 6,7-Dimethoxy-1-(3-pyridyl)isochroman, as claimed in claim 1.
7. 6,7-Dimethoxy-1-(2-pyridyl)isochroman, as claimed in claim 1.
8. 1-(2-Thienyl)-6-isochromanol, as claimed in claim 1.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.