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Details for Patent: 4,349,477

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Details for Patent: 4,349,477

Title: Process for producing imidazodiazepines
Abstract:This invention is directed toward pharmacologically active compound of the formula ##STR1## wherein A is ##STR2## R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, hydroxy lower alkyl, acyloxy lower alkyl, phenyl, alkoxy lower alkyl, halo lower alkyl, amino lower alkyl, substituted amino lower alkyl, substituted phenyl, pyridyl, aralkyl and the groups ##STR3## wherein R is hydrogen or lower alkyl and ROOC where R is lower alkyl; R.sub.2 is selected from the group consisting of hydrogen, lower alkyl, hydroxy lower alkyl, acyloxy lower alkyl, alkoxy lower alkyl, halo lower alkyl, amino or substituted amino lower alkyl, amino, cyano, cyano lower alkyl, substituted amino, chloro, bromo and iodo, the group --COOR where R is hydrogen or lower alkyl, the group ##STR4## where R is hydrogen or lower alkyl, or derivatives thereof, e.g., the group R--C.dbd.N--R' wherein R' is hydrogen, lower alkyl, hydroxy, phenyl, alkoxy, amino, mono or di-alkylamino and arylamino and R is hydrogen or lower alkyl, the group ##STR5## (where R and R' are individually hydrogen, lower alkyl, hydroxy lower alkyl, lower alkenyl, aryl or together R and R' form a part of a heterocyclic ring and the group (CH.sub.2).sub.n NRR' where R and R' are hydrogen, lower alkyl, hydroxy lower alkyl, lower alkenyl or together R and R' form a part of a heterocyclic ring and n is 1 to 4); the group ##STR6## where R.sup.10, R.sup.11, R.sup.12 are hydrogen or lower alkyl and the group (CH.sub.2).sub.n NR.sup.13 R.sup.14 where n is 1 to 4 and R.sup.13, R.sup.14 are hydrogen, lower alkyl, hydroxy lower alkyl, lower alkenyl or R.sup.13 and R.sup.14 together form part of a heterocyclic ring, with the limitation that where R.sup.10, R.sup.11 or R.sup.12 is a basic side chain, then the remaining substituents are hydrogen or lower alkyl; R.sub.3 is selected from the group consisting of hydrogen and lower alkyl; R.sub.5 is selected from the group consisting of hydrogen, lower alkanoyloxy and hydroxy; R.sub.4 is selected from the group consisting of hydrogen, halogen, nitro, cyano, trifluoromethyl, lower alkyl, substituted amino, amino, hydroxy lower alkyl and lower alkanoyl; R.sub.6 is selected from the group consisting of phenyl, mono-substituted phenyl, di-substituted phenyl, pyridyl and mono-substituted pyridyl; and ##STR7## is selected from the group consisting of ##STR8## and the pharmaceutically acceptable salts thereof. Also provided are methods for the preparation of these compounds as well as pharmaceutical formulations which contain the active compounds of this invention. The compounds of the formulas illustrated above and their analogs are useful as anticonvulsants, muscle relaxants, anxiolytic and sedative agents.
Inventor(s): Walser; Armin (West Caldwell, NJ), Fryer; Rodney I. (North Caldwell, NJ)
Assignee: Hoffmann-La Roche Inc. (Nutley, NJ)
Filing Date:Mar 12, 1981
Application Number:06/243,026
Claims:1. A process to produce a compound of the formula ##STR95## wherein A is ##STR96## R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, phenyl, alkoxy lower alkyl, pyridyl, and tolyl; R is hydrogen or lower alkyl; R.sub.3 is selected from the group consisting of hydrogen and lower alkyl; R.sub.4 is selected from the group consisting of hydrogen, halogen, nitro, cyano, trifluoromethyl, lower alkyl, hydroxy lower alkyl and lower alkanoyl; R.sub.6 is selected from the group consisting of phenyl, mono-halo or mono-nitro substituted phenyl, di-halo or halo-nitro substituted phenyl, pyridyl and mono-halo or mono-nitro substituted pyridyl; and ##STR97## is selected from the group consisting of ##STR98## which comprises the stepwise reaction of a compound of the formula ##STR99## wherein A, R.sub.3, R.sub.4 and ##STR100## are as above (a) with the anion generated from acylamino malonic ester, i.e., a compound of the formula ##STR101## wherein R is lower alkyl and R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, phenyl, alkoxy lower alkyl, pyridyl and tolyl;

(b) decarboxylating the product of (a) with an alkali metal alkoxide;

(c) dehydrating the product of (b) to produce the final product.

2. A process to produce a compound of the formula ##STR102## wherein R.sub.1 ' is selected from the group consisting of phenyl, and pyridyl; R is selected from the group consisting of lower alkoxy and NR'R" where R' and R" are lower alkyl; R.sub.3 is selected from the group consisting of hydrogen and lower alkyl; R.sub.6 is selected from the group consisting of phenyl, mono-halo or mono-nitro substituted phenyl, dihalo or halo-nitro substituted phenyl, pyridyl and mono-halo or mono-nitro substituted pyridyl; and R.sub.4 is selected from the group consisting of hydrogen, halogen, nitro, cyano, trifluoromethyl, lower alkyl, mono- or di-C.sub.1 to C.sub.7 alkyl or phenyl, chlorophenyl or tolyl substituted amino, and lower alkanoyl; which comprises reacting a compound of the formula ##STR103## wherein R.sub.3 is as above; R.sub.4 is as above; and R.sub.6 is as above with a compound of the formula ##STR104## wherein R.sub.1 ' is selected from the group consisting of phenyl, and pyridyl and R is selected from the group consisting of lower alkoxy and NR'R" where R' and R" are lower alkyl in the presence of a strong base at below room temperature and subsequently allowing the reaction mixture to warm to room temperature.
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