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Details for Patent: 4,340,605

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Details for Patent: 4,340,605

Title: Thiazolidine derivatives
Abstract:Thiazolidine derivatives of the general formula: ##STR1## [wherein R.sup.1 is alkyl, cycloalkyl, phenylalkyl, phenyl, a five- or six-membered heterocyclic group including one or two hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur or a group of the formula ##STR2## (where R.sup.3 and R.sup.4 are the same or different and each is lower alkyl or R.sup.3 and R.sup.4 are combined to each other either directly or as interrupted by a hetero-atom selected from the group consisting of nitrogen, oxygen and sulfur to form a five- or six-membered ring); R.sup.2 means a bond or a lower alkylene group; L.sup.1 and L.sup.2 are the same or different and each is lower alkyl or L.sup.1 and L.sup.2 are combined to form an alkylene group, provided that when R.sup.1 is other than alkyl, L.sup.1 and L.sup.2 may further be hydrogen, respectively] are novel compounds and useful as, for example, remedies for diabetes, hyperlipemia and so on of mammals including human beings.
Inventor(s): Kawamatsu; Yutaka (Kyoto, JP), Fujita; Takeshi (Takarazuka, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Filing Date:Apr 29, 1981
Application Number:06/258,554
Claims:1. A thiazolidine derivative of the general formula: ##STR79## wherein R.sup.1 is pyridyl or thiazolyl; R.sup.2 means a bond or a lower alkylene group; L.sup.1 and L.sup.2 are the same or different and each is hydrogen, lower alkyl or L.sup.1 and L.sup.2 are combined to form an alkylene group.

2. A thiazolidine derivative as claimed in claim 1, wherein L.sup.1 and L.sup.2 are combined to form an alkylene group having 2 to 6 carbon atoms.

3. A thiazolidine derivative as claimed in claim 1, wherein R.sup.2 is a lower alkylene groups having 1 to 3 carbon atoms.

4. A thiazolidine derivative as claimed in claim 1, wherein L.sup.1 and L.sup.2 are combined to form an alkylene group having 2 to 6 carbon atoms and R.sup.2 is a lower alkylene group having 1 to 3 carbon atoms.

5. A hypolipidemic and hypoglycemic pharmaceutical composition, which comprises, as active ingredient, the effective amount of a thiazolidine derivative defined in claim 1.

6. A compound as claimed in claim 1, wherein the compound is 5-[4-{2-(3-pyridyl)ethoxy}benzyl]thiazolidine-2,4-dione.

7. A compound as claimed in claim 1, wherein the compound is 5-[4-{2-(2-pyridyl)ethoxy}-benzyl]thiazolidine-2,4-dione.
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