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Details for Patent: 4,339,437

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Details for Patent: 4,339,437

Title: Anti-tumor method
Abstract:Malignant tumor cells sensitive to platinum coordination compounds in animals are treated by parenterally administering to an affected animal a solution containing a complex compound of platinum in an amount effective to cause regression of the tumor.
Inventor(s): Rosenberg; Barnett (Holt, MI), VanCamp; Loretta (East Lansing, MI), Krigas; Thomas (Okemos, MI)
Assignee: Research Corporation (New York, NY)
Filing Date:Jul 26, 1979
Application Number:06/060,961
Claims:1. a method of treating animal malignant tumor cells sensitive to a planar dsp.sup.2 platinum(II) coordination compound or an ochtahedral d.sup.2 sp.sup.3 platinum(IV) coordination compound wherein the donor ligands are Cl, Br, CN, NO.sub.3, ethylene diamine, propylene diamine, pyridine, H.sub.2 O, OH, OS, in animals which comprises parenterally administering to an animal afflicted with said tumor cells a solution containing one of said compounds in an amount sufficient to cause regression of the animal tumor cells.

2. A method according to claim 1 wherein the solution is administered in multiple doses.

3. A method according to claim 1 wherein the solution is administered in a single dose.

4. A method according to claim 1 wherein the compound is administered in a saline or salt-containing buffer solution.

5. A method according to claim 1 wherein the compound is a chloroplatinumammine.

6. A method according to claim 1 wherein the compound is cis-Pt(IV)(NH.sub.3).sub.2 Cl.sub.4.

7. A method according to claim 1 wherein the compound is Pt(II)(NH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2)Cl.sub.2.

8. A method according to claim 1 wherein the compound is Pt(IV)(NH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2)Cl.sub.4.
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