|Title:|| PGI.sub.2 Lower alkyl esters|
|Abstract:||The present invention relates to PGI.sub.2 lower alkyl esters, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.|
|Inventor(s):|| Johnson; Roy A. (Kalamazoo, MI), Lincoln; Frank H. (Portage, MI), Pike; John E. (Kalamazoo, MI) |
|Assignee:|| The Upjohn Company (Kalamazoo, MI) |
|Filing Date:||Mar 27, 1981|
|Claims:||1. A compound of the formula ##STR2## or a mixture comprising that compound and the enantiomer thereof, wherein R.sub.3 is alkyl of one to 4 carbon atoms, inclusive; including the lower alkanoates thereof. |
2. (5Z)-9-Deoxy-6,9.alpha.-epoxy-.DELTA..sup.5 -PGF.sub.1, methyl ester, a compound according to claim 1.
3. (5Z)-9-Deoxy-6,9.alpha.-epoxy-.DELTA..sup.5 -PGF.sub.1, methyl ester, 11,15-diacetate, a compound according to claim 1.