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Details for Patent: 4,330,559

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Details for Patent: 4,330,559

Title: Method of treating benign prostatic hypertrophy
Abstract:There is described a method for treating benign prostatic hypertrophy comprising the administration of 2,5-di-amino-2-(mono-,di-, or trifluoromethyl)pentanoic acid or derivative thereof.
Inventor(s): Bey; Philippe (Strasbourg, FR), Jung; Michel (Illkirch Groffenstaden, FR)
Assignee: Merrell-Toraude et Cie (Strasbourg, FR)
Filing Date:Feb 03, 1981
Application Number:06/231,072
Claims:1. A method of treating benign prostatic hypertrophy in a patient in need thereof which comprises the administration to said patient of an effective amount of a compound of the formula ##STR15## wherein: Y is FCH.sub.2 --, F.sub.2 CH--, or F.sub.3 C--;

R.sub.a and R.sub.b are, independently, hydrogen, (C.sub.1 -C.sub.4)alkylcarbonyl, or the group ##STR16## wherein R.sub.2 is hydrogen, (C.sub.1 -C.sub.4) alkyl, benzyl, or p-hydroxybenzyl;

R.sub.1 is hydroxy, (C.sub.1 -C.sub.8)alkoxy, the group --NR.sub.4 R.sub.5, wherein R.sub.4 and R.sub.5 are, independently, hydrogen, or, (C.sub.1 -C.sub.4)alkyl, or the group ##STR17## wherein R.sub.3 is hydrogen, (C.sub.1 -C.sub.4) alkyl, benzyl, or p-hydroxybenzyl;

or the pharmaceutically acceptable salts or individual optical isomers thereof.

2. A method as defined in claim 1 wherein Y is --CH.sub.2 F or --CHF.sub.2.

3. A method as defined in claim 1 or 2 wherein R.sub.1 is hydroxy.

4. A method as defined in claim 1 or 2 wherein R.sub.1 is hydroxy and R.sub.a is hydrogen.

5. A method as defined in claim 1 or 2 wherein R.sub.1 is hydroxy and R.sub.b is hydrogen.

6. A method as defined in claim 1 or 2 wherein R.sub.a and R.sub.b are hydrogen.

7. A method as defined in claim 2 which comprises the administration of 2,5-diamino-2-fluoromethylpentanoic acid.

8. A method as defined in claim 2 which comprises the administration of 2,5-diamino-2-difluoromethylpentanoic acid.
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