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Generated: February 19, 2018

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Title: 3,4-Dihydrocarbostyril derivatives
Abstract:Novel compounds represented by the formula ##STR1## wherein R.sup.1, R.sup.2, R' and R" are defined as hereinafter, having a blocking activity on .beta.-adrenergic nerves, novel intermediates useful for synthesis thereof and processes for preparing the same are disclosed. When substitution is at the 5-position and R.sup.1 and R.sup.2 are hydrogen, R' and R" are not simultaneously hydrogen and a 1 to 4 carbon atom alkyl group in the claimed compound.
Inventor(s): Nakagawa; Kazuyuki (Tokushima, JP), Murakami; Nanami (Tokushima, JP), Yoshizaki; Shiro (Komatsujima, JP), Mori; Hideo (Tokushima, JP), Tominaga; Michiaki (Tokushima, JP)
Assignee: Otsuka Pharmaceutical Co., Ltd. (Tokyo, JP)
Filing Date:Jun 24, 1980
Application Number:06/162,353
Claims:1. Novel 3,4-dihydrocarbostyril derivatives represented by the formula ##STR67## wherein R.sup.1 is selected from the group consisting of a hydrogen atom, a straight or branched alkyl group having 1 to 4 carbon atoms, an unsubstituted phenylalkyl group having 1 to 4 carbon atoms in the alkyl moiety and an alkenyl group having 2 to 4 carbon atoms, and Z represents a group of the formula ##STR68## wherein Y represents a halogen atom.

2. 5-(3-Chloro-2-hydroxy)propoxy-3,4-dihydrocarbostyril according to claim 1.
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