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Generated: January 23, 2018

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Title: Preparation of ammonium salt of hypocholesteremic fermentation product
Abstract:Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.
Inventor(s): Albers-Schonberg; George (Princeton, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Filing Date:Aug 11, 1980
Application Number:06/176,816
Claims:1. A process for the isolation of the compound ##STR6## as its ammonium salt from a fermentation broth obtained from the cultivation of microorganisms identified as Aspergillus terreus with Accession numbers ATCC 20541 and ATCC 20542 which comprises the steps of:

(a) acidifying whole broth;

(b) extracting with a water-immiscible, inert, organic solvent;

(c) extracting the organic solvent extract with aqueous alkali;

(d) acidifying the aqueous extract;

(e) extracting the aqueous extract with a water-immiscible, inert, organic solvent;

(f) drying the organic solvent extract; and

(g) treating the organic solvent extract with gaseous ammonia.

2. The process of claim 1 wherein acidification is with phosphoric acid to about pH 5 and the immiscible organic solvent is ethyl acetate or mixtures of n-hexane-ethyl acetate.
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