Flexible Flat-Rate Plans

Flat-rate pricing for predictable budgeting

Short-term plans for project- or client-based billing

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 4,319,039

« Back to Dashboard

Details for Patent: 4,319,039

Title: Preparation of ammonium salt of hypocholesteremic fermentation product
Abstract:Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.
Inventor(s): Albers-Schonberg; George (Princeton, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Filing Date:Aug 11, 1980
Application Number:06/176,816
Claims:1. A process for the isolation of the compound ##STR6## as its ammonium salt from a fermentation broth obtained from the cultivation of microorganisms identified as Aspergillus terreus with Accession numbers ATCC 20541 and ATCC 20542 which comprises the steps of:

(a) acidifying whole broth;

(b) extracting with a water-immiscible, inert, organic solvent;

(c) extracting the organic solvent extract with aqueous alkali;

(d) acidifying the aqueous extract;

(e) extracting the aqueous extract with a water-immiscible, inert, organic solvent;

(f) drying the organic solvent extract; and

(g) treating the organic solvent extract with gaseous ammonia.

2. The process of claim 1 wherein acidification is with phosphoric acid to about pH 5 and the immiscible organic solvent is ethyl acetate or mixtures of n-hexane-ethyl acetate.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.