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Details for Patent: 4,309,442

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Details for Patent: 4,309,442

Title: Method for controlling fertility in mammals
Abstract:A method for preventing gestation in mammals comprising the administration of a 2,5-diamino-2-halomethylpentanoic acid or derivative thereof.
Inventor(s): Bey; Philippe (Strasbourg, FR), Jung; Michel (Illkirch Graffenstaden, FR)
Assignee: Merrell Toraude et Compagnie (Strasbourg, FR)
Filing Date:Dec 03, 1980
Application Number:06/212,473
Claims:1. A method of preventing gestation in mammals which comprises the administration to said mammals of a contragestationally effective amount of a compound of the formula: ##STR14## wherein: Y is FCH.sub.2 --, F.sub.2 CH--, or F.sub.3 C--;

R.sub.a and R.sub.b are, independently, hydrogen, (C.sub.1 -C.sub.4)alkylcarbonyl, or the group ##STR15## wherein R.sub.2 is hydrogen, (C.sub.1 -C.sub.4) alkyl, benzyl, or p-hydroxybenyl;

R.sub.1 is hydroxy, (C.sub.1 -C.sub.8) alkoxy, the group --NR.sub.4 R.sub.5, wherein R.sub.4 and R.sub.5 are, independently, hydrogen, or, (C.sub.1 -C.sub.4)alkyl, or the group ##STR16## wherein R.sub.3 is hydrogen, (C.sub.1 -C.sub.4) alkyl, benzyl, or p-hydroxybenzyl; and the pharmaceutically acceptable salts and individual optical isomers thereof.

2. A method as defined in claim 1 wherein Y is --CH.sub.2 F or --CHF.sub.2.

3. A method as defined in claim 1 or 2 wherein R.sub.1 is hydroxy.

4. A method as defined in claim 1 or 2 wherein R.sub.1 is hydroxy and R.sub.a is hydrogen.

5. A method as defined in claim 1 or 2 wherein R.sub.1 is hydroxy and R.sub.b is hydrogen.

6. A method as defined in claim 1 or 2 wherein R.sub.a and R.sub.b are hydrogen.

7. A method as defined in claim 2 which comprises the administration of 2,5-diamino-2-fluoromethylpentanoic acid.

8. A method as defined in claim 2 which comprises the administration of 2,5-diamino-2-diamino-2-difluoromethylpentanoic acid.
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