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|Title:||Hypocholesteremic fermentation products and process of preparation|
|Abstract:||Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise a compound designated MSD803 which has the lactone structure: ##STR1## as well as its free hydroxy acid form. Together with salts and esters of the free acid form, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.|
|Inventor(s):||Monaghan; Richard L. (Somerset, NJ), Alberts; Alfred W. (Short Hills, NJ), Hoffman; Carl H. (Scotch Plains, NJ), Albers-Schonberg; George (Princeton, NJ)|
|Assignee:||Merck & Co., Inc. (Rahway, NJ)|
|Filing Date:||Jan 23, 1980|
|Claims:||1. A process of producing a compound of the formula: ##STR5## or its corresponding free acid which comprises fermenting a microorganism of the genus Aspergillus terreus and isolating the product thereof. |
2. The process of claim 1 in which said microorganism is one deposited in the American Type Culture Collection with accession number 20541 or 20542.
3. The process of claim 1 in which the said isolation comprises extraction of a clarified aqueous solution of said fermentation mixture with a solvent followed by chromatography.