Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Queensland Health
Boehringer Ingelheim

Generated: June 22, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,294,926

« Back to Dashboard

Title: Hypocholesteremic fermentation products and process of preparation
Abstract:Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise a compound designated MSD803 which has the lactone structure: ##STR1## as well as its free hydroxy acid form. Together with salts and esters of the free acid form, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.
Inventor(s): Monaghan; Richard L. (Somerset, NJ), Alberts; Alfred W. (Short Hills, NJ), Hoffman; Carl H. (Scotch Plains, NJ), Albers-Schonberg; George (Princeton, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Filing Date:Jan 23, 1980
Application Number:06/114,458
Claims:1. A process of producing a compound of the formula: ##STR5## or its corresponding free acid which comprises fermenting a microorganism of the genus Aspergillus terreus and isolating the product thereof.

2. The process of claim 1 in which said microorganism is one deposited in the American Type Culture Collection with accession number 20541 or 20542.

3. The process of claim 1 in which the said isolation comprises extraction of a clarified aqueous solution of said fermentation mixture with a solvent followed by chromatography.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Queensland Health
Chinese Patent Office
Johnson and Johnson
Farmers Insurance
Cantor Fitzgerald

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.