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Queensland Health

Generated: January 22, 2018

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Title: Hypocholesteremic fermentation products and process of preparation
Abstract:Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise a compound designated MSD803 which has the lactone structure: ##STR1## as well as its free hydroxy acid form. Together with salts and esters of the free acid form, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.
Inventor(s): Monaghan; Richard L. (Somerset, NJ), Alberts; Alfred W. (Short Hills, NJ), Hoffman; Carl H. (Scotch Plains, NJ), Albers-Schonberg; George (Princeton, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Filing Date:Jan 23, 1980
Application Number:06/114,458
Claims:1. A process of producing a compound of the formula: ##STR5## or its corresponding free acid which comprises fermenting a microorganism of the genus Aspergillus terreus and isolating the product thereof.

2. The process of claim 1 in which said microorganism is one deposited in the American Type Culture Collection with accession number 20541 or 20542.

3. The process of claim 1 in which the said isolation comprises extraction of a clarified aqueous solution of said fermentation mixture with a solvent followed by chromatography.
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Serving leading biopharmaceutical companies globally:

Argus Health
Daiichi Sankyo
Cantor Fitzgerald
Federal Trade Commission
US Department of Justice

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