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Generated: February 23, 2018

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Title: 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-e thyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones
Abstract:The title compounds are prepared by saponifying the corresponding 8-acyloxy compounds, with strong base at elevated temperatures to remove the hindered acyl group without disrupting the rest of the molecule. The products are useful as intermediates in the synthesis of antihypercholesterolemia agents.
Inventor(s): Willard; Alvin K. (Lansdale, PA)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Filing Date:Aug 05, 1980
Application Number:06/175,232
Claims:1. A compound of the formula ##STR38## in which the dotted lines X, Y and Z represent possible double bonds, said double bonds, when any are present, being either X and Z in combination or one of X, Y or Z alone.

2. A compound of claim 1 in which X and Z represent double bonds.

3. A compound of claim 1 in which X is a double bond.

4. A compound of claim 1 in which Y is a double bond.

5. A compound of claim 1 in which Z is a double bond.

6. A compound of claim 1 in which none of X, Y or Z is a double bond.
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Serving leading biopharmaceutical companies globally:

Chubb
Julphar
Daiichi Sankyo
Medtronic
Chinese Patent Office
Cipla
US Department of Justice
Teva
Mallinckrodt
QuintilesIMS

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